NDLI: Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy.

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Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moldenhauer, Lachlan M. Hayball, John D. Robertson, Sarah A.
Description	Country affiliation: Australia Author Affiliation: Moldenhauer LM ( Research Centre for Reproductive Health, School of Paediatric and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia. lachlan.moldenhauer@adelaide.edu.au)
Abstract	Studies in mice demonstrate that the maternal T cell repertoire is aware of paternal antigens during pregnancy, but in healthy pregnancy reactive T cells do not mediate anti-fetal immunity. Mice expressing transgenic T cell receptors (TCRs) specific for paternal and conceptus antigens are powerful tools for elucidating the events surrounding paternal antigen presentation to the maternal T cell repertoire, the nature of the ensuing T cell response and the factors that skew the response towards immune tolerance to allow survival and development of the conceptus. While results from different transgenic TCR models are not always consistent, there is now sufficient data to allow a consensus interpretation that maternal antigen presenting cells present initially seminal fluid antigens and later placenta-derived antigens to both the CD4+ and CD8+ T cell repertoire. T cell proliferation is generally followed by entry into a state of anergy demonstrated by decreased cytokine production and hyporesponsiveness upon restimulation. Some models also demonstrate downregulation of the TCR and co-stimulatory molecules, clonal deletion of paternal antigen-reactive T cells, or alternatively T cell ignorance of paternal antigens. This review will summarise the range of transgenic TCR studies that have shed light on the events surrounding paternal antigen presentation and the various T cell responses to insemination and pregnancy. The benefits, limitations and caveats of these models, and their impact upon data interpretation, are discussed.
File Format	HTM / HTML
ISSN	01650378
Issue Number	1-2
Volume Number	87
e-ISSN	18727603
Journal	Journal of Reproductive Immunology
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Discipline Reproductive Medicine Antigen Presentation Fetus Immunology Immune Tolerance Pregnancy Receptors, Antigen, T-cell Animals Antigen-presenting Cells Cd4-positive T-lymphocytes Cd8-positive T-lymphocytes Clonal Deletion Cytokines Biosynthesis Female Insemination Lymphocyte Activation Mice Mice, Transgenic Genetics Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Reproductive Medicine Obstetrics and Gynecology

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