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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hamadi, Nasereddine Mansour, Ahmed Hassan, Memy H. Khalifi-Touhami, Fatima Badary, Osama |
| Description | Country affiliation: Algeria Author Affiliation: Hamadi N ( Department of Biology, Mentouri Mahmoud University, Constantine, Algeria.) |
| Abstract | The objective of this study was to investigate the ameliorative property and potential mechanism of resveratrol (RVT) in a dose of 10 mg/kg for 15 consecutive days against liver injury in streptozotocin-induced diabetic rats. Diabetic rats significantly (P < 0.05) exhibited liver injury manifested by increased aspartylaminotransferase, alanine aminotransferase, and bilirubin; disturbed liver weight to body weight; and confirmed by hematoxylin and eosin staining. Liver from diabetic rats exhibited significant increase in malondialdehyde level and significant decrease in reduced glutathione, glutathione-S-transferase, quinone reductase, catalase, and superoxide dismutase. Diabetic rats showed significant disturbance in serum lipid profile. Treatment with RVT significantly (P < 0.05) abrogated diabetes-induced perturbation in these parameters and liver histology. These data suggest that RVT treatment is associated with promising hepatoprotective effect against diabetes-induced liver damage via reduction of serum glucose level and oxidative damage and improving serum lipid profile. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 10 |
| Volume Number | 26 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Anti-inflammatory Agents Therapeutic Use Antioxidants Diabetes Mellitus, Experimental Drug Therapy Liver Diseases Stilbenes Animals Pharmacology Blood Glucose Blood Complications Lipid Peroxidation Lipids Liver Drug Effects Metabolism Pathology Etiology Male Malondialdehyde Organ Size Oxidative Stress Rats Rats, Sprague-dawley Streptozocin Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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