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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rajarajeswari, Narayanasamy Pari, Leelavinothan |
| Description | Country affiliation: India Author Affiliation: Rajarajeswari N ( Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, India.) |
| Abstract | The purpose of this study was to investigate the antioxidant role of coumarin on streptozotocin-nicotinamide-induced Type 2 diabetic rats. In experimental rats, the levels of plasma glucose, insulin, and the levels of thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes, and the activities of superoxide dismutase, catalase, glutathione-S-transferase, and glutathione peroxidase were assayed in liver and kidney. Diabetic rats showed elevated levels of plasma glucose and lipid peroxidation markers and reduced plasma insulin and antioxidant enzymes. Oral administration of coumarin resulted in a significant reduction in the plasma glucose and lipid peroxides and a significant increase in the plasma insulin and antioxidant enzymes. Chronic treatment of coumarin remarkably restored the normal status of the histopathological changes observed in the selected tissues. It can be concluded that coumarin has antioxidant effect in Type 2 diabetic rats. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 6 |
| Volume Number | 25 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Antioxidants Therapeutic Use Coumarins Diabetes Mellitus, Experimental Drug Therapy Diabetes Mellitus, Type 2 Animals Administration & Dosage Pharmacology Blood Glucose Metabolism Enzymology Insulin Blood Kidney Lipid Peroxides Liver Male Molecular Structure Rats Rats, Wistar Streptozocin Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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