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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Zhong-Ning Lin, Yu-Chun Zhang, Xuemei Kadlubar, Susan Tuo, Jingsheng Green, Bridgett Deng, Helen Ning, Baitang |
| Description | Country affiliation: United States Author Affiliation: Lin ZN ( Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.) |
| Abstract | Previously, we reported five common single nucleotide polymorphisms (SNPs), -624G>C, -396G>A, -358A>C, -341C>G, and -294T>C, and six common haplotypes (CGACT, GAACT, GGAGC, GGACC, CAACT, and GAACC) in the 5'-flanking region of the SULT1A1 gene that were associated with altered enzymatic activity. In the present study, we performed in vitro assays to determine the functional impact of these genetic variations on the promoter activity. Dual luciferase reporter assays revealed that these SNPs are located in a negative regulatory fragment of the SULT1A1 gene. Further experiments demonstrated that these SNPs and haplotypes affected promoter activities of SULT1A1. Electrophoretic mobility shift assays showed distinctive binding patterns for the SNPs -396G>A and -294T>C, due to differential binding affinities of the G/A alleles and the T/C alleles to nuclear proteins extracted from the liver carcinoma cell lines, HepG2 and Huh7. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 10 |
| Volume Number | 26 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Arylsulfotransferase Genetics Haplotypes Polymorphism, Single Nucleotide Promoter Regions, Genetic 5' Flanking Region Metabolism Base Sequence Cell Nucleus Electrophoretic Mobility Shift Assay Genes, Reporter Genetic Association Studies Hep G2 Cells Humans Luciferases, Renilla Biosynthesis Protein Binding Transcriptional Activation Journal Article Research Support, U.s. Gov't, P.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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