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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hong, Sang-Won Jung, Kyung Hee Zheng, Hong-Mei Lee, Hee-Seung Suh, Jun-Kyu Park, In-Suh Lee, Don-Haeng Hong, Soon-Sun |
| Description | Author Affiliation: Hong SW ( Department of Biomedical Sciences and Clinical Research Center, College of Medicine, Inha University, Incheon, 400-711, Korea.) |
| Abstract | Oxidative stress in liver injury is a major pathogenetic factor in progress of liver fibrosis. Resveratrol, a representative antioxidant derived from grapes, has been reported to show widespread pharmacological properties. In this study, we investigated the protective effects of resveratrol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Rats were treated with resveratrol daily by oral gavage for seven days after a single intraperitoneal injection of DMN (40 mg/kg). Resveratrol remarkably recovered body and liver weight loss due to DMN-induced liver fibrosis. Liver histology showed that resveratrol alleviated the infiltration of inflammatory cells and fibrosis of liver tissue. Resveratrol decreased the level of malondialdehyde and increased the levels of glutathione peroxidase and superoxide dismutase. Also, resveratrol significantly inhibited the mRNA expression of inflammatory mediators including inducible nitric oxide, tumor necrosis factor-alpha and interleukin-1beta. In addition, resveratrol showed not only reduced mRNA expression of fibrosis-related genes such as transforming growth factor beta 1, collagen type I, and alpha-smooth muscle actin, but also a significant decrease of hydroxyproline in rats with DMN-induced liver fibrosis. Our results suggest that resveratrol could be used to treat liver injury and fibrosis and be useful in preventing the development of liver fibrosis and cirrhosis. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 4 |
| Volume Number | 33 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-04-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antioxidants Therapeutic Use Dimethylnitrosamine Liver Cirrhosis, Experimental Prevention & Control Liver Drug Effects Stilbenes Animals Administration & Dosage Metabolism Biological Markers Blood Body Weight Lipid Peroxidation Enzymology Immunology Pathology Chemically Induced Male Organ Size Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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