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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Patel, Tapan A. Rao, Mandava V. |
| Description | Country affiliation: India Author Affiliation: Patel TA ( a Department of Zoology , Human Genetics Center, School of Sciences, Gujarat University , Ahmedabad , Gujarat , India.); Rao MV ( a Department of Zoology , Human Genetics Center, School of Sciences, Gujarat University , Ahmedabad , Gujarat , India.) |
| Abstract | Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as melatonin (0.2 mM), curcumin (3.87 µM) and andrographolide (0.4 µM) were evaluated against the genotoxic effect of mercury. All the experiments were conducted using the peripheral blood lymphocytes In Vitro. The cultures were exposed to different doses (2.63 µM; 6.57 µM; 10.52 µM) of mercury salt (HgCl2) for studying various genotoxic indices. All three antioxidant compounds, alone and in combination with high dose of mercury, were added to the cultures with controls. For ascertaining genotoxicity, sister chromatid exchanges (SCEs), cell cycle proliferative index/replicative index (CCPI/RI), average generation time (AGT), population doubling time (PDT), %M1, %M2 and %M3 were assessed and analyzed using suitable statistical analysis. The results revealed a dose dependent increase in SCEs, AGT and PDT, with a concomitant reduction in CCPI values after treatment of mercury. Supplementation of these three antioxidant compounds effectively negated these genotoxic endpoints in treated cultures with improvement in the cell cycle kinetics i.e. CCPI. The antimutagenic activity of these compounds on mercury induced genotoxicity was in the following order: melatonin > curcumin > andrographolide. In conclusion, these compounds have ameliorated mercury induced increase in genotoxic indices due to their excellent antioxidant properties and the combination seems to be effective. |
| File Format | HTM / HTML |
| ISSN | 01480545 |
| Issue Number | 4 |
| Volume Number | 38 |
| e-ISSN | 15256014 |
| Journal | Drug and Chemical Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Antimutagenic Agents Pharmacology Antioxidants Mercuric Chloride Toxicity Mutagens Adult Cell Cycle Drug Effects Cells, Cultured Curcumin Diterpenes Dose-response Relationship, Drug Humans Lymphocytes Pathology Male Melatonin Administration & Dosage Mutagenicity Tests Sister Chromatid Exchange Young Adult Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
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