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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sabuncuoglu, Suna Eken, Ayse Aydin, Ahmet Ozgunes, Hilal Orhan, Hilmi |
| Description | Country affiliation: Turkey Author Affiliation: Sabuncuoglu S ( a Department of Toxicology, Faculty of Pharmacy , Hacettepe University , Ankara , Turkey .); Eken A ( b Department of Toxicology, Faculty of Pharmacy , Erciyes University , Kayseri , Turkey .); Aydin A ( c Department of Toxicology, Faculty of Pharmacy , Yeditepe University , Istanbul , Turkey , and.); Ozgunes H ( a Department of Toxicology, Faculty of Pharmacy , Hacettepe University , Ankara , Turkey .); Orhan H ( d Department of Toxicology, Faculty of Pharmacy , Ege University , Izmir , Turkey.) |
| Abstract | We explored the association between the activities of antioxidant enzymes and their metallic cofactors in rats treated with cisplatin. The antioxidant effects of aminoguanidine, and a combination of vitamins E and C were investigated. Plasma platin was significantly lower than liver and kidney. Cisplatin treatment caused significant increase in plasma Se-glutathione peroxidase activity. Activities of Se-glutathione peroxidase, glutathione S-transferase, catalase and Cu,Zn-superoxide dismutase have been found to be significantly decreased in liver and kidney compared to controls. Zn levels in these organs were diminished upon cisplatin treatment, while levels of Cu were unaffected. Interestingly, levels of iron, the cofactor of catalase, were found to be significantly increased in liver and kidney. Intervention with aminoguanidine or vitamins was generally prevented cisplatin-caused changes in the activity of enzymes and in the tissue levels of cofactor metals. These observations suggest that relation between activities of enzymes and levels of cofactor metals is multifactorial. |
| File Format | HTM / HTML |
| ISSN | 01480545 |
| Issue Number | 4 |
| Volume Number | 38 |
| e-ISSN | 15256014 |
| Journal | Drug and Chemical Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Antioxidants Metabolism Cisplatin Toxicity Coenzymes Enzymes Animals Antineoplastic Agents Administration & Dosage Pharmacology Ascorbic Acid Catalase Chemistry Glutathione Peroxidase Glutathione Transferase Guanidines Kidney Liver Male Metals Rats Rats, Sprague-dawley Superoxide Dismutase Vitamin E Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
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