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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sasu, Alciona Herman, Hildegard Mariasiu, Teodora Rosu, Marcel Balta, Cornel Anghel, Nicoleta Miutescu, Eftimie Cotoraci, Coralia Hermenean, Anca |
| Description | Country affiliation: Romania Author Affiliation: Sasu A ( a Department of Hematology, Faculty of Medicine , Pharmacy and Dentistry, Vasile Goldis Western University of Arad , Arad , Romania .); Herman H ( b Institute of Life Sciences, Vasile Goldis Western University of Arad , Arad , Romania .); Mariasiu T ( c Department of Histology , and.); Rosu M ( b Institute of Life Sciences, Vasile Goldis Western University of Arad , Arad , Romania .); Balta C ( b Institute of Life Sciences, Vasile Goldis Western University of Arad , Arad , Romania .); Anghel N ( c Department of Histology , and.); Miutescu E ( d Department of Gastroenterology, Faculty of Medicine , Pharmacy and Dentistry, Vasile Goldis Western University of Arad , Arad , Romania.); Cotoraci C ( a Department of Hematology, Faculty of Medicine , Pharmacy and Dentistry, Vasile Goldis Western University of Arad , Arad , Romania .); Hermenean A ( b Institute of Life Sciences, Vasile Goldis Western University of Arad , Arad , Romania .) |
| Abstract | Mucositis is a serious disorder of the gastrointestinal tract that results from cancer chemotherapy. We investigated the protective effects of silymarin on epirubicin-induced mucosal barrier injury in CD-1 mice. Immunohistochemical activity of both pro-apoptotic Bax and anti-apoptotic Bcl-2 markers, together with p53, cyt-P450 expression and DNA damage analysis on stomach, small intestine and colon were evaluated. Our results indicated stronger expression for cyt P450 in all analyzed gastrointestinal tissues of Epi group, which demonstrate intense drug detoxification. Bax immunopositivity was intense in the absorptive enterocytes and lamina connective cells of the small intestine, surface epithelial cells of the stomach and also in the colonic epithelium and lamina concomitant with a decreased Bcl-2 expression in all analyzed tissues. Epirubicin-induced gastrointestinal damage was verified by a goblet cell count and morphology analysis on histopathological sections stained for mucins. In all analyzed tissues, Bax immunopositivity has been withdrawn by highest dose of silymarin concomitant with reversal of Bcl-2 intensity at a level comparable with control. p53 expression was found in all analyzed tissues and decreased by high dose of silymarin. Also, DNA internucleosomal fragmentation was observed in the Epi groups for all analyzed tissues was almost suppressed at 100 mg/kg Sy co-treatment. Histological aspect and goblet cell count were restored at a highest dose of Sy for both small and large intestine. In conclusion, our findings suggest that silymarin may prevent cellular damage of epirubicin-induced toxicity and was effective in reducing the severity indicators of gastrointestinal mucositis in mice. |
| File Format | HTM / HTML |
| ISSN | 01480545 |
| Issue Number | 4 |
| Volume Number | 38 |
| e-ISSN | 15256014 |
| Journal | Drug and Chemical Toxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Apoptosis Drug Effects Epirubicin Toxicity Mucositis Prevention & Control Silymarin Pharmacology Animals Antibiotics, Antineoplastic Cytochrome P-450 Enzyme System Metabolism Dna Damage Dna Fragmentation Dose-response Relationship, Drug Gastric Mucosa Pathology Gastrointestinal Diseases Chemically Induced Intestinal Mucosa Mice Protective Agents Administration & Dosage Proto-oncogene Proteins C-bcl-2 Severity Of Illness Index Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
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