NDLI: Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures.

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Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures.

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Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pant, Hemlata Hemant Rao, Mandava Venkateshvara
Description	Country affiliation: India Author Affiliation: Pant HH ( Biochemistry Department, P D Patel Institute of Applied Sciences, Education Campus Changa, Charotar University of Science and Technology, At&PO Petlad, Anand, 388 421, Gujarat, India. hemlata.pant@gmail.com)
Abstract	Melatonin has been known for its anti-oxidant potential but not much studied for the anti-genotoxic potential. The current study elucidate the role of melatonin against in vitro genotoxicity by arsenic (As) and fluoride (F). Human peripheral blood cultures were exposed to As (1.4 microM) and F (34 microM), alone and in combination, with and without melatonin (0.2 mM). Ethyl methane sulphonate (EMS; 1.9 mM) was selected as the positive control to analyze the genotoxic parameters like sister chromatid exchanges (SCEs), cell cycle proliferative index (CCPI) and primary DNA damage. The frequency of SCE/cell, SCE/chromosome and primary DNA damage reduced significantly (p<0.001) accompanied with a marked increase in CCPI upon addition of melatonin. Similarly marked recovery was attained by melatonin from As and F induced primary DNA damage as studied using comet assay. The results clearly indicate towards the protection of lymphocytes from toxic effects af As and F by melatonin in vitro.
File Format	HTM / HTML
ISSN	01476513
Issue Number	6
Volume Number	73
e-ISSN	10902414
Journal	Ecotoxicology and Environmental Safety
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Sciences Antimutagenic Agents Pharmacology Dna Damage Lymphocytes Drug Effects Melatonin Mutagens Toxicity Water Pollutants, Chemical Adult Arsenic Cells, Cultured Comet Assay Fluorides Humans Metabolism Sister Chromatid Exchange Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health

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Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures.

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