NDLI: Tetramethylpyrazine protects lymphocytes from radiation-induced apoptosis through nuclear factor-κB.

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Tetramethylpyrazine protects lymphocytes from radiation-induced apoptosis through nuclear factor-κB.

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Tetramethylpyrazine protects lymphocytes from radiation-induced apoptosis through nuclear factor-κB.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Xiao-Yan Ma, Zeng-Chun Wang, Yu-Guang Tan, Hong-Ling Xiao, Cheng-Rong Liang, Qian-De Tang, Xiang-Lin Cheng, Yu Gao, Yue
Description	Country affiliation: China Author Affiliation: Wang XY ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China); Ma ZC ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China. Electronic address: 13681121635@139.com.); Wang YG ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.); Tan HL ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.); Xiao CR ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.); Liang QD ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.); Tang XL ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China.); Cheng Y ( Chongqing Maternal and Child Health-Care Hospital, Chongqing 400016, China.); Gao Y ( Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China. Electronic address: gaoyue@bmi.ac.cn.)
Abstract	AIM: Radiation induces an important apoptosis response in irradiated organs. The objective of this study was to investigate the radioprotective effect of tetramethylpyrazine (TMP) on irradiated lymphocytes and discover the possible mechanism of protection. METHOD: Lymphocytes were pretreated for 12 h with TMP (25-200 µmol·L(-1)) and then exposed to 4 Gy radiation. Cell apoptosis and the signaling pathway were analyzed. RESULTS: Irradiation increased cell death, DNA fragmentation, activated caspase activation and cytochrome c translocation, downregulated B-cell lymphoma 2 (Bcl-2) and up-regulated Bcl-2-associated X protein (Bax). Pretreated with TMP significantly reversed this tendency. Several anti-apoptotic characteristics of TMP, including the ability to increase cell viability, inhibit caspase-9 activation, and upregulate Bcl-2 and down-regulate Bax in 4Gy-irradiated lymphocytes were determined. Signal pathway analysis showed TMP could translate nuclear factor-κB (NF-κB) from cytosol into the nucleus. CONCLUSION: The results suggest that TMP had a radioprotective effect through the NF-κB pathway to inhibit apoptosis, and it may be an effective candidate for treating radiation diseases associated with cell apoptosis.
File Format	HTM / HTML
ISSN	20956975
Issue Number	10
Volume Number	12
e-ISSN	18755364
Journal	Chinese Journal of Natural Medicines
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Publisher Place	China
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Apoptosis Drug Effects Radiation Effects Drugs, Chinese Herbal Pharmacology Lymphocytes Nf-kappa B Metabolism Pyrazines Radiation-protective Agents Cell Line Cell Survival Dna Fragmentation Humans Cytology Genetics Proto-oncogene Proteins C-bcl-2 Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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