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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sathiavelu, Jayanthi Senapathy, Giftson Jebakkan Devaraj, Rajkumar Namasivayam, Nalini |
| Description | Country affiliation: India Author Affiliation: Sathiavelu J ( Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.) |
| Abstract | OBJECTIVES: To evaluate the effect of chrysin, a natural, biologically active compound extracted from many plants, honey and propolis, on the tissue and circulatory antioxidant status, and lipid peroxidation in ethanol-induced hepatotoxicity in rats. METHODS: Rats were divided into four groups. Groups 1 and 2 received isocaloric glucose. Groups 3 and 4 received 20% ethanol, equivalent to 5 g/kg bodyweight every day. Groups 2 and 4 received chrysin (20 mg/kg bodyweight) dissolved in 0.5% dimethylsulfoxide. KEY FINDINGS: The results showed significantly elevated levels of tissue and circulatory thiobarbituric acid reactive substances, conjugated dienes and lipid hydroperoxides, and significantly lowered enzymic and non-enzymic antioxidant activity of superoxide dismutase, catalase and glutathione-related enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in ethanol-treated rats compared with the control. Chrysin administration to rats with ethanol-induced liver injury significantly decreased the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevated the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and the levels of reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those of the unsupplemented ethanol-treated rats. The histological changes observed in the liver and kidney correlated with the biochemical findings. CONCLUSIONS: Chrysin offers protection against free radical-mediated oxidative stress in rats with ethanol-induced liver injury. |
| File Format | HTM / HTML |
| ISSN | 00223573 |
| Issue Number | 6 |
| Volume Number | 61 |
| e-ISSN | 20427158 |
| Journal | Journal of Pharmacy and Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2009-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antioxidants Metabolism Ethanol Toxicity Flavonoids Therapeutic Use Liver Diseases, Alcoholic Drug Therapy Oxidative Stress Drug Effects Protective Agents Animals Ascorbic Acid Catalase Female Pharmacology Glutathione Glutathione Peroxidase Glutathione Transferase Kidney Pathology Lipid Peroxidation Liver Rats Rats, Wistar Superoxide Dismutase Vitamin E Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmaceutical Science |
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