NDLI: Clinical research strategies for fructose metabolism.

Please wait, while we are loading the content...

Centers for Disease Control and Prevention. 2013. Strategies to Prevent Obesity and Other Chronic Diseases: The CDC Guide to Strategies to Support Breastfeeding Mothers and Babies. Atlanta, GA: U.S. Department of Health and Human Services, 2013.

Comment on 'Limitations of observational evidence: implications for evidence-based dietary recommendations'.

Comment on 'Limitations of observational evidence: implications for evidence-based dietary recommendations'. Reply to Ankarfeldt.

Proceedings of the International Union of Nutritional Sciences (IUNS) 20th International Congress of Nutrition.

Principles and pitfalls in the differential diagnosis and management of childhood obesities.

Bioactive foods and ingredients for health.

Chronobiology and obesity: Interactions between circadian rhythms and energy regulation.

Toward body composition reference data for infants, children, and adolescents.

Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study.

Identifying and characterizing the effects of nutrition on hippocampal memory.

Micronutrient research, programs, and policy: From meta-analyses to metabolomics.

Nutritional phenotype databases and integrated nutrition: from molecules to populations.

The FINUT healthy lifestyles guide: Beyond the food pyramid.

Personalized nutrition and cardiovascular disease prevention: From Framingham to PREDIMED.

Year: 2014 Volume: 5 Issue: 2

Year: 2014 Volume: 5 Issue: 1

Clinical research strategies for fructose metabolism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Laughlin, Maren R. Bantle, John P. Havel, Peter J. Parks, Elizabeth Klurfeld, David M. Teff, Karen Maruvada, Padma
Description	Country affiliation: Moldova Author Affiliation: Laughlin MR ( National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD maren.laughlin@nih.gov.); Bantle JP ( Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN.); Havel PJ ( Department of Molecular Biosciences, Department of Nutrition, School of Veterinary Medicine, University of California, Davis, Davis, CA.); Parks E ( Department of Nutrition and Exercise Physiology, Institute for Clinical Translational Science, University of Missouri, Columbia, MO); Klurfeld DM ( USDA, Agricultural Research Service, Beltsville, MD.); Teff K ( National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD.); Maruvada P ( National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD.)
Abstract	Fructose and simple sugars are a substantial part of the western diet, and their influence on human health remains controversial. Clinical studies in fructose nutrition have proven very difficult to conduct and interpret. NIH and USDA sponsored a workshop on 13-14 November 2012, 'Research Strategies for Fructose Metabolism,' to identify important scientific questions and parameters to be considered while designing clinical studies. Research is needed to ascertain whether there is an obesogenic role for fructose-containing sugars via effects on eating behavior and energy balance and whether there is a dose threshold beyond which these sugars promote progression toward diabetes and liver and cardiovascular disease, especially in susceptible populations. Studies tend to fall into 2 categories, and design criteria for each are described. Mechanistic studies are meant to validate observations made in animals or to elucidate the pathways of fructose metabolism in humans. These highly controlled studies often compare the pure monosaccharides glucose and fructose. Other studies are focused on clinically significant disease outcomes or health behaviors attributable to amounts of fructose-containing sugars typically found in the American diet. These are designed to test hypotheses generated from short-term mechanistic or epidemiologic studies and provide data for health policy. Discussion brought out the opinion that, although many mechanistic questions concerning the metabolism of monosaccharide sugars in humans remain to be addressed experimentally in small highly controlled studies, health outcomes research meant to inform health policy should use large, long-term studies using combinations of sugars found in the typical American diet rather than pure fructose or glucose.
File Format	HTM / HTML
ISSN	21618313
e-ISSN	21565376
DOI	10.3945/an.113.005249
Journal	Advances in Nutrition: An International Review Journal
Issue Number	3
Volume Number	5
Language	English
Publisher	Oxford University Press
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Biomedical Research Fructose Adverse Effects Metabolism Animals Carbohydrates Administration & Dosage Cardiovascular Diseases Epidemiology Clinical Trials As Topic Diet Disease Models, Animal Energy Metabolism Drug Effects Feeding Behavior Health Behavior Meta-analysis As Topic Metabolic Diseases Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine Food Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism.

Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials.

Dietary strategies for the management of cardiovascular risk: role of dietary carbohydrates.

Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.

Fructose: it's 'alcohol without the buzz'.

Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials.

Dietary fructose and glucose differentially affect lipid and glucose homeostasis.

Metabolic profiling in nutrition and metabolic disorders.

Role of dietary fats in the prevention and treatment of the metabolic syndrome.

Clinical research strategies for fructose metabolism.

Similar Documents

Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism.

Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials.

Dietary strategies for the management of cardiovascular risk: role of dietary carbohydrates.

Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.

Fructose: it's 'alcohol without the buzz'.

Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials.

Dietary fructose and glucose differentially affect lipid and glucose homeostasis.

Metabolic profiling in nutrition and metabolic disorders.

Role of dietary fats in the prevention and treatment of the metabolic syndrome.

Clinical research strategies for fructose metabolism.