NDLI: Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials.

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Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aronis, Konstantinos N. Khan, Sami M. Mantzoros, Christos S.
Description	Country affiliation: United States Author Affiliation: Aronis KN ( Section of Endocrinology, Department of Internal Medicine, VA Boston Healthcare System, Boston, MA, USA.)
Abstract	BACKGROUND: Although evidence from cohort studies has suggested that trans fatty acid (TFA) consumption may be associated with insulin resistance and diabetes, randomized placebo-controlled trials (RCTs) have yielded conflicting results. OBJECTIVE: In a meta-analysis, we combined all available RCTs that examined the role of TFA intake on glucose homeostasis. DESIGN: A systematic review of PubMed was performed, and a total of 7 RCTs were included in the meta-analysis. Primary outcomes were glucose and insulin concentrations. Secondary outcomes were total, LDL-, and HDL-cholesterol and triglyceride concentrations. The pooled effect size (ES) was calculated through fixed- and random-effects meta-analyses. The potential existence of publication bias was evaluated by using funnel-plot analysis. Metaregression analysis was performed to evaluate for potential dose-response relations between the ES of outcomes and TFA intake. RESULTS: Increased TFA intake did not result in significant changes in glucose or insulin concentrations. Increased TFA intake led to a significant increase in total and LDL-cholesterol [ES (95% CI): 0.28 (0.04, 0.51) and 0.36 (0.13, 0.60), respectively] and a significant decrease in HDL-cholesterol concentrations [ES (95% CI): -0.25 (-0.48, -0.01)]. Our analysis also showed the absence of publication bias and any dose-response relations between the ES and TFA intake. CONCLUSIONS: Increased TFA intake does not result in changes in glucose, insulin, or triglyceride concentrations but leads to an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol concentrations. There is no evidence to support a potential benefit of the reduction of dietary TFA intake on glucose homeostasis.
File Format	HTM / HTML
ISSN	00029165
e-ISSN	19383207
DOI	10.3945/ajcn.112.040576
Journal	American Journal of Clinical Nutrition
Issue Number	5
Volume Number	96
Language	English
Publisher	American Society for Nutrition
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Glucose Metabolism Insulin Trans Fatty Acids Administration & Dosage Cholesterol Homeostasis Drug Effects Randomized Controlled Trials As Topic Triglycerides Meta-analysis Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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