NDLI: The tumor macroenvironment and systemic regulation of breast cancer progression.

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Ecosystems of invasion and metastasis in mammary morphogenesis and cancer.

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From the laboratory to the patient and back--an interview with Marc Mareel. Interview by Marc E. Bracke.

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Signaling networks in cancer--an interview with Christian Gespach. Interview by Olivier De Wever.

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Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland.

Remodeling mechanisms of the mammary gland during involution.

Connexins: a junctional crossroad to breast cancer.

Insulin-like growth factor binding proteins and mammary gland development.

Canine mammary tumors contain cancer stem-like cells and form spheroids with an embryonic stem cell signature.

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P-cadherin role in normal breast development and cancer.

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking.

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.

Role of cancer-associated fibroblasts in breast cancer development and prognosis.

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions.

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis.

Exosome signaling in mammary gland development and cancer.

The tumor macroenvironment and systemic regulation of breast cancer progression.

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The tumor macroenvironment and systemic regulation of breast cancer progression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Castaño, Zafira Tracy, Kristin McAllister, Sandra S.
Description	Country affiliation: United States Author Affiliation: Castaño Z ( Department of Medicine, Hematology Division, Brigham and Women's Hospital, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA. smcallister1@partners.org)
Abstract	Breast cancer is the most common malignancy among women worldwide and is the most common cause of death for women between 35 and 50 years of age. Women with breast cancer are at risk of developing metastases for their entire lifetime and, despite local and systemic therapies, approximately 30% of breast cancer patients will relapse (Jemal et al., 2010). Nearly all breast cancer related deaths are due to metastatic disease, even though metastasis is considered to be an inefficient process. In some cases, tumor cells disseminate from primary sites at an early stage, but remain indolent for protracted periods of time before becoming overt, life-threatening tumors. Little is known about the mechanisms that cause these indolent tumors to grow into malignant disease. Because of this gap in our understanding, we are unable to predict which breast cancer patients are likely to experience disease relapse or develop metastases years after treatment of their primary tumor. A better understanding of the mechanisms and signals involved in the exit of tumor cells from dormancy would not only allow for more accurate selection of patients that would benefit from systemic therapy, but could also lead to the development of more targeted therapies to inhibit the signals that promote disease progression. In this review, we address the systemic, or 'macroenvironmental', contribution to tumor initiation and progression and what is known about how a pro-tumorigenic systemic environment is established.
File Format	HTM / HTML
ISSN	02146282
e-ISSN	16963547
Journal	The International Journal of Developmental Biology
Issue Number	7-9
Volume Number	55
Language	English
Publisher	University of the Basque Country Press
Publisher Date	2011-01-01
Publisher Place	Spain
Access Restriction	Open
Subject Keyword	Discipline Embryology Discipline Biology Breast Neoplasms Etiology Tumor Microenvironment Animals Physiopathology Disease Progression Mice Models, Biological Neoplasm Transplantation Signal Transduction Transplantation, Heterologous Physiology
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Embryology

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