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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mareel, Marc Constantino, Susana |
| Description | Country affiliation: Belgium Author Affiliation: Mareel M ( Department of Radiotherapy and Experimental Cancer Research, University Hospital Ghent, De Pintelaan 185, Ghent, Belgium. marc.mareel@ugent.be) |
| Abstract | The present review describes molecular and cellular mechanisms of cancer invasion and metastasis as compared to mammary gland development considering communication inside and between ecosystems. At the level of the individual cell, invasion programs are written by an ecosystem of signalling pathways each of which steers several invasion-related cellular activities. At the supracellular level, communication within the epithelial compartment involves cells of the same origin, but with different phenotypes including stem cells. A similar interaction occurs between the various cells of the stromal compartment. Crucial for our understanding of tumor or mammary gland ecosystems are the mutual interactions between cells of the epithelial and cells of the stromal compartment. An update is provided for endothelial cells, cancer-associated fibroblasts and macrophages that are implicated in angiogenesis, desmoplasia and inflammation respectively. At the level of the organism, distant ecosystems, comprising primary tumor site, sites of metastasis, bone marrow and endocrine glands among others, are in continuous contact through circulating cells and soluble ligands. Our review suggests consideration of these ecosystems when designing therapeutic strategies. |
| File Format | HTM / HTML |
| ISSN | 02146282 |
| e-ISSN | 16963547 |
| Journal | The International Journal of Developmental Biology |
| Issue Number | 7-9 |
| Volume Number | 55 |
| Language | English |
| Publisher | University of the Basque Country Press |
| Publisher Date | 2011-01-01 |
| Publisher Place | Spain |
| Access Restriction | Open |
| Subject Keyword | Discipline Embryology Discipline Biology Breast Neoplasms Pathology Breast Growth & Development Animals Physiopathology Cell Communication Endothelial Cells Physiology Epithelial Cells Mammary Glands, Animal Mammary Neoplasms, Experimental Mice Neoplasm Invasiveness Neoplasm Metastasis Neovascularization, Pathologic Signal Transduction Stem Cell Niche Stromal Cells Tumor Microenvironment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Embryology |
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