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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Albergaria, André Ribeiro, Ana-Sofia Vieira, André-Filipe Sousa, Bárbara Nobre, Ana-Rita Seruca, Raquel Schmitt, Fernando Paredes, Joana |
| Description | Country affiliation: Portugal Author Affiliation: Albergaria A ( Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, Porto, Portugal.) |
| Abstract | P-cadherin is a cell-cell adhesion molecule, whose expression is highly associated with undifferentiated cells in normal adult epithelial tissues, as well as with poorly differentiated carcinomas. Its expression has been already reported in human embryonic stem cells and it is presumed to be a marker of stem or progenitor cells of some epithelial tissues. In normal breast, P-cadherin has an essential role during ductal mammary branching, being expressed by the monolayer of epithelial cap cells at the end buds. In mature mammary tissue, its expression is restricted to the myoepithelium; it has been postulated that it may also be present in early luminal progenitor cells. In breast cancer, P-cadherin is frequently overexpressed in high-grade tumours, being a well-established indicator of poor patient prognosis. It has been reported as an important inducer of cancer cell migration and invasion, with underlying molecular mechanisms involving the signalling mediated by its juxtamembrane domain, the secretion of matrix metalloproteases to the extracellular media, and the cleavage of a P-cadherin soluble form with pro-invasive activity. Intracellularly, this protein interferes with the endogenous cadherin/catenin complex, inducing p120-catenin delocalization to the cytoplasm, and the consequent activation of Rac1/Cdc42 and associated alterations in the actin cytoskeleton. Considering P-cadherin's role in cancer cell invasion and metastasis formation, a humanized monoclonal antibody was recently produced to antagonize P-cadherin-associated signalling pathways, which is currently under Phase I clinical trials. In this review, the most important findings about the role of P-cadherin in normal breast development and cancer will be illustrated and discussed, with emphasis on the most recent data. |
| File Format | HTM / HTML |
| ISSN | 02146282 |
| e-ISSN | 16963547 |
| Journal | The International Journal of Developmental Biology |
| Issue Number | 7-9 |
| Volume Number | 55 |
| Language | English |
| Publisher | University of the Basque Country Press |
| Publisher Date | 2011-01-01 |
| Publisher Place | Spain |
| Access Restriction | Open |
| Subject Keyword | Discipline Embryology Discipline Biology Breast Neoplasms Etiology Breast Growth & Development Cadherins Physiology Animals Tumor Markers, Biological Embryology Pathology Physiopathology Genetics Cell Adhesion Cell Differentiation Cell Movement Epigenesis, Genetic Epithelial-mesenchymal Transition Mammary Glands, Animal Mammary Neoplasms, Experimental Mice Models, Biological Neoplasm Invasiveness Neoplastic Stem Cells Prognosis Signal Transduction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Embryology |
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