NDLI: Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats.

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Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mohan-Kumari, H. P. Dhale, Mohan A. Akhilender Naidu, K. Vijayalakshmi, G.
Description	Country affiliation: India Author Affiliation: Mohan-Kumari HP ( Department of Food Microbiology, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore, India.)
Abstract	The effect of Monascus purpureus red mould rice (RMR) on modulation of lipid metabolism and oxidative stress was studied in hypercholesterolemic rats. Cholesterol feeding for 14 weeks caused a significant increase in the lipid peroxides and total thiols and antioxidant enzymes, viz. glutathione peroxidase (GPx), glutathione reductase (GRd), superoxide dismutase (SOD) and catalase (CAT) in serum and liver in comparison to the control group. However, supplementation of RMR to hypercholesterolemic rats at 8, 12 and 16% significantly increased the GRd, GPx, SOD and CAT activities in serum and liver tissues. Furthermore, RMR feeding significantly decreased total thiols and lipid peroxides and also increased other antioxidant molecules such as glutathione and ascorbic acid in high-cholesterol fed rats. The efficiency of RMR (16%) in modulating the antioxidant molecules and antioxidant enzymes is comparable to standard drug-lovastatin. Thus, this study suggests that the long-term administration of RMR may play an important role in suppressing oxidative stress and, thus, may be useful for the prevention and/or early treatment of hypercholesterolemia.
File Format	HTM / HTML
ISSN	02636484
Issue Number	7
Volume Number	29
e-ISSN	10990844
Journal	Cell Biochemistry and Function
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Biochemistry Antioxidants Metabolism Hypercholesterolemia Drug Therapy Oryza Sativa Chemistry Animals Ascorbic Acid Catalase Cholesterol Blood Fermentation Glutathione Reductase Enzymology Lipid Peroxidation Liver Lovastatin Pharmacology Male Monascus Microbiology Oxidative Stress Rats Rats, Wistar Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Clinical Biochemistry

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