NDLI: S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line

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S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line

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S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jiang, Weifeng Jia, Qianxin Liu, Lili Zhao, Xinwen Tan, Aixing Ma, Ningqiang Zhang, Helong
Description	Country affiliation: China Author Affiliation: Jiang W ( Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.)
Abstract	Brain metastasis frequently occurs in cancer patients and is associated with a poor prognosis. We previously reported that S100B was highly expressed in PC14/B, a specific brain metastatic lung adenocarcinoma cell line, which suggests that it is associated with brain metastasis of lung cancer. However, the role of S100B in brain metastasis remains to be elucidated. In this study, using PC14/B cell line, we found that siRNA mediated depletion of S100B in PC14/B cells led to notable differences in cell proliferation, apoptosis, cell cycle progression, colony formation ability, cell migratory and invasive activity compared with the mock-transfected cells. Therefore, our data suggest that S100B promotes the brain metastasis of lung adenocarcinoma by promoting cell proliferation, preventing apoptosis and increasing cell migration and invasion. Copyright © 2011 John Wiley & Sons, Ltd.
File Format	HTM / HTML
ISSN	02636484
Issue Number	7
Volume Number	29
e-ISSN	10990844
Journal	Cell Biochemistry and Function
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Biochemistry Adenocarcinoma Pathology Brain Neoplasms Secondary Gene Expression Regulation, Neoplastic Lung Neoplasms Nerve Growth Factors Metabolism S100 Proteins Genetics Apoptosis Blotting, Western Bromodeoxyuridine Cell Line, Tumor Cell Movement Cell Proliferation Gene Knockdown Techniques Humans Neoplasm Invasiveness Rna, Small Interfering S100 Calcium Binding Protein Beta Subunit Transfection Bcl-x Protein Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Clinical Biochemistry

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S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line

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