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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ben Amara, Ibtissem Soudani, Nejla Hakim, Ahmed Bouaziz, Hanen Troudi, Afef Zeghal, Khaled Mounir Zeghal, Najiba |
| Description | Country affiliation: Tunisia Author Affiliation: Ben Amara I ( Animal Physiology Laboratory, Sfax Faculty of Science, University of Sfax, Sfax, Tunisia.) |
| Abstract | Pesticide hazards have been accentuated by the sharp rise in their agricultural, industrial and domestic use. Acute exposure to pesticides can cause oxidative damage. Our study investigated the potential ability of selenium (Se) and/or vitamin E, used as nutritional supplements, to alleviate erythrocyte oxidative damage induced by dimethoate (DM), an organophosphate pesticide. Female Wistar rats were exposed to DM (0.2g/L(-1) of drinking water), DM + Se (0.5 mg/kg of diet), DM + vitamin E (100 mg/kg of diet), or DM + Se + vitamin E. Rats exposed to DM for 30 days showed an increase in malondialdehyde levels, superoxide dismutase and glutathione peroxidase activities in their erythocytes, while Na(+),K(+)-ATPase and catalase activities, glutathione, non-protein thiol, vitamin E and vitamin C levels decreased. We also noted an increase in lactate dehydrogenase activity, marker of haemolysis and a decrease in acetylcholinesterase, the principal mode of organophosphorus action. Co-administration of Se or vitamin E to the diet of DM-treated rats ameliorated the biochemical parameters cited above. But the combined effect of Se and vitamin E was more powerful in antagonizing DM-induced oxidative stress. Therefore, our investigation revealed that both Se and vitamin E were useful elements in preventing DM-induced erythrocytes damage. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 3 |
| Volume Number | 28 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Dimethoate Toxicity Erythrocytes Drug Effects Oxidative Stress Selenium Pharmacology Vitamin E Analysis Of Variance Animals Antioxidants Ascorbic Acid Dietary Supplements Eating Enzymology Metabolism Female Lipid Peroxidation Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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