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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdou, Rania H. Abdel-Daim, Mohamed M. |
| Description | Country affiliation: Egypt Author Affiliation: Abdou RH ( a Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.) |
| Abstract | Alpha-lipoic acid (ALA) is a natural dithiol compound, with a free radical scavenger and biological antioxidant properties. The purpose of the current study was to investigate the protective effects of ALA on biochemical alteration and oxidative stress induced by acute deltamethrin intoxication in rats. Markers of liver and kidney injuries in serum of deltamethrin-intoxicated as well as ALA-pretreated rats were analyzed. Moreover, serum and (or) tissue lipid peroxidation, malondialdehyde and antioxidant markers, reduced glutathione, catalase, superoxide dismutase activity, and total antioxidant capacity were evaluated. The results showed that all parameters were altered in the intoxicated group, indicating hepatorenal oxidative damage of deltamethrin. Pre-treatment with ALA reversed the changes in most of the studied parameters in a dose-dependent manner. Histopathological and biochemical findings were parallel. It can be concluded that ALA may be a promising therapeutic option for prevention and (or) treatment of deltamethin toxicity. |
| File Format | HTM / HTML |
| ISSN | 00084212 |
| e-ISSN | 12057541 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Issue Number | 9 |
| Volume Number | 92 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2014-09-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Antioxidants Pharmacology Free Radical Scavengers Insecticides Toxicity Nitriles Pyrethrins Thioctic Acid Animals Biological Markers Metabolism Catalase Glutathione Kidney Drug Effects Pathology Lipid Peroxidation Liver Malondialdehyde Oxidative Stress Superoxide Dismutase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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