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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gupta, Ramesh K. Hussain, Talib Panigrahi, G. Das, Avik Singh, Gireesh Narayan Sweety, K. Faiyazuddin, Md Rao, Chandana Venkateswara |
| Description | Country affiliation: India Author Affiliation: Gupta RK ( Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow, Uttar Pradesh, India.) |
| Abstract | OBJECTIVE: To investigate the hepatoprotective potential of Solanum xanthocarpum (Solanaceae) (S. xanthocarpum) in experimental rats to validate its traditional claim. METHODS: 50% ethanolic fruit extract of S. xanthocarpum (SXE, 100, 200 or 400 mg/kg body weight) was administered daily for 14 days in experimental animals. Liver injury was induced chemically, by CCl(4) administration (1 mL/kg i. p.). The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), Serum alkaline phosphatise (SALP) and total bilirubin. Meanwhile, in vivo antioxidant activities as lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were screened along with histopathological studies. RESULTS: Obtained results demonstrated that the treatment with SXE significantly (P<0.05-<0.001) and dose-dependently prevented chemically induced increase in serum levels of hepatic enzymes. Furthermore, SXE significantly (up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and catalase towards normal levels. Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. CONCLUSIONS: The results of this study strongly indicate the protective effect of SXE against acute liver injury which may be attributed to its hepatoprotective activity, and there by scientifically support its traditional use. |
| File Format | HTM / HTML |
| ISSN | 19957645 |
| e-ISSN | 23524146 |
| Journal | Asian Pacific Journal of Tropical Medicine |
| Issue Number | 12 |
| Volume Number | 4 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-12-01 |
| Publisher Place | China |
| Access Restriction | Open |
| Subject Keyword | Discipline Tropical Medicine Drug-induced Liver Injury Drug Therapy Liver Drug Effects Phytotherapy Plant Extracts Pharmacology Solanum Alanine Transaminase Blood Alkaline Phosphatase Animals Aspartate Aminotransferases Carbon Tetrachloride Catalase Etiology Dose-response Relationship, Drug Glutathione Lipid Peroxidation Enzymology Medicine, Traditional Mice Rats, Sprague-dawley Superoxide Dismutase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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