NDLI: Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of Kâ º channels: Components identification through TLC.

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Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of Kâ º channels: Components identification through TLC.

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Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of Kâ º channels: Components identification through TLC.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Khan, Haroon Saeed, Muhammad Gilani, Anwarul-Hassan Muhammad, Naveed Ur Rehman, Najeeb Mehmood, Malik Hassan Ashraf, Nadeem
Description	Country affiliation: Pakistan Author Affiliation: Khan H ( Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.); Saeed M ( Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.); Gilani AH ( Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan Department of Basic Medical Sciences, Faculty of Pharmacy, Gomal University, Khyber-Pakhtoonkha, Pakistan.); Muhammad N ( Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.); Ur Rehman N ( Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.); Mehmood MH ( Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan.); Ashraf N ( International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.)
Abstract	Polygonatum verticillatum has traditionally been used for various purposes. The present study was aimed to validate the antispasmodic and antidiarrheal properties of crude methanolic extract of rhizomes of P. verticillatum (PR). Isolated rabbit jejunum preparations were suspended in tissue baths to measure the isotonic responses using Power Lab data acquisition system for the antispasmodic activity of PR, while the antidiarrheal activity was conducted in vivo in mice. PR caused complete relaxation of the spontaneous contractions of isolated rabbit jejunum preparations in a dose-dependent mode. A complete inhibition was observed against low potassium (K(+); 25 mM)-induced contractions, while the plant extract partially inhibited the high K(+)(80 mM)-induced contractions. From a mechanistic point of view, the spasmolytic effect of PR against low K(+)was antagonized by glibenclamide similar to the effect of cromakalim, thus showing the presence of constituents in PR mediating spasmolytic activity predominantly through the activation of adenosine triphosphate-sensitive K(+)channels. When tested against castor oil-induced diarrhea in mice, oral administration of the plant extract manifested marked antidiarrheal activity at the doses of 500 and 1000 mg/kg similar to loperamide. This study provided a pharmacological basis for the medicinal use of PR in abdominal colic and diarrhea.
File Format	HTM / HTML
ISSN	07482337
Issue Number	4
Journal	Toxicology and Industrial Health
Volume Number	32
e-ISSN	14770393
Language	English
Publisher	Sage Publications
Publisher Date	2016-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Occupational Medicine Discipline Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology

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Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of Kâ º channels: Components identification through TLC.

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