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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Anar, Mustafa Orhan, Furkan Alpsoy, Lokman Gulluce, Medine Aslan, Ali Agar, Guleray |
| Description | Country affiliation: Turkey Author Affiliation: Anar M ( Department of Biology Education, Kazim Karabekir Faculty of Education, Ataturk University, Erzurum, Turkey.); Orhan F ( Central Research and Application Laboratories, Agri Ibrahim Cecen University, Agri, Turkey Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey furkan_orhan@hotmail.com.); Alpsoy L ( Department of Biology, Faculty of Science, Fatih University, Istanbul, Turkey.); Gulluce M ( Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.); Aslan A ( Department of Biology Education, Kazim Karabekir Faculty of Education, Ataturk University, Erzurum, Turkey.); Agar G ( Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey.) |
| Abstract | In this article, the genotoxic and antigenotoxic effects of methanol extract of of Cladonia foliacea (Huds.) Willd. (CME) were studied using WP2, Ames (TA1535 and TA1537), and sister chromatid exchange (SCE) test systems. The results of our studies showed that 5 µM concentration of aflatoxin B1(AFB1) changed the frequencies of SCE and malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) activities. When 5 and 10 µg/mL concentrations of CME was added to AFB1, the frequencies of SCE and MDA level were decreased and SOD, GSH, and GPx levels were increased. The extract CME did not show any mutagenicity on Ames (Salmonella typhimurium TA1535, TA1537) and WP2 (Escherichia coli) test systems. On the other hand, CME has antimutagenicity on the mentioned test systems. The results of this experiment have clearly shown that CME has a significant antioxidative and antigenotoxic effect, which is thought to be due to the antigenotoxic activities of antioxidant enzymes. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 4 |
| Journal | Toxicology and Industrial Health |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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