NDLI: Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.

Please wait, while we are loading the content...

Anti-inflammatory Montelukast prevents toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Oxidative stress, histological alterations in liver, and serum cytokine levels.

The effect of di-n-butyl phthalate on testis and the potential protective effects of resveratrol.

Irreversible thyroid disruption induced after subchronic exposure to hexachlorobenzene in male rats.

A probable role of blood lead levels on some haematological parameters in traffic police, Lahore, Pakistan.

Chemotherapy-induced acral erythema with involvement of the face and neck: A case report.

Dose-dependent genotoxicity of copper oxide nanoparticles stimulated by reactive oxygen species in human lung epithelial cells.

Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy.

Phytochemical analysis, antibacterial, and antifungal assessment of aerial parts of Polygonatum verticillatum.

Changes of c-Myc and DNMT1 mRNA and protein levels in the rat livers induced by dibutyl phthalate treatment.

Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes.

In vivo antinociceptive and anticonvulsant activity of extracts of Heliotropium strigosum.

Enzymatic and histopathologic biomarkers in the flatfish Euryglossa orientalis from the northwestern Persian Gulf.

Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.

Activation of Janus kinase/signal transducers and activators of transcription pathway involved in megakaryocyte proliferation induced by vanadium resembles some aspects of essential thrombocythemia.

The application of FLUENT in simulating outcomes from chlorine leakage accidents in a typical chemical factory.

Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.

Evaluation of intravenous lipid emulsion on haloperidol-induced hypotension in rabbits.

Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF- /NF-κB, and pro-fibrotic factor TGF-ß1 mediating inflammatory signaling.

Year: 2016 Volume: 32 Issue: 4

Year: 2016 Volume: 32 Issue: 3

Year: 2016 Volume: 32 Issue: 2

Year: 2016 Volume: 32 Issue: 1

Year: 2016

Year: 2015 Volume: 31

Year: 2014 Volume: 30

Year: 2013 Volume: 29

Year: 2012 Volume: 28

Year: 2011 Volume: 27

Year: 2010 Volume: 26

Year: 2009 Volume: 25

Year: 2008 Volume: 24

Year: 2006 Volume: 22

Year: 2002 Volume: 18

Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rizk, Maha Z. Aly, Hanan F. Abo-Elmatty, Dina M. Desoky, M. M. Ibrahim, N. Younis, Eman A.
Description	Country affiliation: Egypt Author Affiliation: Rizk MZ ( Department of Therapeutical Chemistry, National Research Center, Cairo, Egypt.); Aly HF ( Department of Therapeutical Chemistry, National Research Center, Cairo, Egypt han201355@yahoo.com.); Abo-Elmatty DM ( Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailiya, Egypt.); Desoky MM ( Department of Pharmacognosy, National Research Center, Cairo, Egypt.); Ibrahim N ( Department of Pharmacognosy, National Research Center, Cairo, Egypt.); Younis EA ( Department of Therapeutical Chemistry, National Research Center, Cairo, Egypt.)
Abstract	This study aims to evaluate two proteins derived from the seeds of the plants Cajanus cajan (Leguminosae) and Caesalpinia gilliesii (Leguminosae) for their abilities to ameliorate the toxic effects of chronic doses of acetoaminphen (APAP) through the determination of certain biochemical parameters including liver marker enzymes: alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. Also, total protein content and hepatic marker enzyme, lactate dehydrogenase were studied. Moreover, liver antioxidants, glutathione (GSH), nitric oxide, and lipid peroxides were determined in this study. Hepatic adenosine triphosphatase (ATPase), adenylate energy charge (ATP, adenosine diphosphate, adenosine monophosphate, and inorganic phosphate), and phosphate potential, serum interleukin-6, tumor necrosis factor- , and myeloperoxidase were also examined in the present study. On the other hand, histopathological examination of intoxicated and liver treated with both proteins was taken into consideration. The present results show disturbances in all biochemical parameters and hepatic toxicity signs including mild vascular congestion, moderate inflammatory changes with moderate congested sinusoids, moderate nuclear changes (pyknosis), moderate centrilobular necrosis, fatty changes, nuclear pyknosis vascular congestion, and change in fatty centrilobular necrosis liver. Improvement in all biochemical parameters studied was noticed as a result of treatment intoxicated liver with C. gilliesii and C. cajan proteins either paracetamol with or post paracetamol treatment. These results were documented by the amelioration signs in rat's hepatic architecture. Thus, both plant protein extracts can upregulate and counteract the inflammatory process, minimize damage of the liver, delay disease progression, and reduce its complications.
File Format	HTM / HTML
ISSN	07482337
Issue Number	5
Journal	Toxicology and Industrial Health
Volume Number	32
e-ISSN	14770393
Language	English
Publisher	Sage Publications
Publisher Date	2016-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Occupational Medicine Discipline Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Therapeutic and protective effects of Caesalpinia gilliesii and Cajanus cajan proteins against acetaminophen overdose-induced renal damage.

Antioxidant and Hepatoprotective Effect of Cajanus cajan in N-Nitrosodiethylamine-Induced Liver Damage

Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus.

Carbon tetrachloride-induced kidney damage and protective effect of Amaranthus lividus L. in rats.

Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.

Chromium-induced skin damage among Taiwanese cement workers.

Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats.

Protective function of cis-mulberroside A and oxyresveratrol from Ramulus mori against ethanol-induced hepatic damage.

Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats.

Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.

Similar Documents

Therapeutic and protective effects of Caesalpinia gilliesii and Cajanus cajan proteins against acetaminophen overdose-induced renal damage.

Antioxidant and Hepatoprotective Effect of Cajanus cajan in N-Nitrosodiethylamine-Induced Liver Damage

Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus.

Carbon tetrachloride-induced kidney damage and protective effect of Amaranthus lividus L. in rats.

Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.

Chromium-induced skin damage among Taiwanese cement workers.

Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats.

Protective function of cis-mulberroside A and oxyresveratrol from Ramulus mori against ethanol-induced hepatic damage.

Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats.

Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage.