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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yilmaz, Dilek Teksoy, Ozgun Bilaloglu, Rahmi Çinkilic, Nilufer |
| Description | Country affiliation: Turkey Author Affiliation: Yilmaz D ( a Department of Biology , Faculty of Science and Arts, Cell Culture and Genetic Toxicology Laboratory, Uludag University Görükle , Bursa , Turkey.); Teksoy O ( a Department of Biology , Faculty of Science and Arts, Cell Culture and Genetic Toxicology Laboratory, Uludag University Görükle , Bursa , Turkey.); Bilaloglu R ( a Department of Biology , Faculty of Science and Arts, Cell Culture and Genetic Toxicology Laboratory, Uludag University Görükle , Bursa , Turkey.); Çinkilic N ( a Department of Biology , Faculty of Science and Arts, Cell Culture and Genetic Toxicology Laboratory, Uludag University Görükle , Bursa , Turkey.) |
| Abstract | Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 µg/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 µg/mL. Combined treatments of BLM and naringin (2 and 3 µg/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that naringin could prevent BLM (20 µg/mL)-induced genotoxicity. |
| File Format | HTM / HTML |
| ISSN | 01480545 |
| Issue Number | 2 |
| Journal | Drug and Chemical Toxicology |
| Volume Number | 39 |
| e-ISSN | 15256014 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety |
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