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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Uygur, Ramazan Aktas, Cevat Caglar, Veli Uygur, Emine Erdogan, Hasan Ozen, Oguz Aslan |
| Description | Country affiliation: Turkey Author Affiliation: Uygur R ( Department of Anatomy, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey fztramazan@hotmail.com.); Aktas C ( Department of Histology and Embryology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.); Caglar V ( Department of Anatomy, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.); Uygur E ( Vocational School of Health Services, Namik Kemal University, Tekirdag, Turkey.); Erdogan H ( Department of Physiology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.); Ozen OA ( Department of Anatomy, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.) |
| Abstract | This study aimed to investigate the protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. A total of 27 male rats were divided into 3 groups: control (saline: 5 ml kg(-1) day(-1), intragastrically), arsenic (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically), and arsenic + melatonin (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically and melatonin: 25 mg kg(-1) day(-1), intraperitoneally) group. At the end of 30 days, the rats were killed under anesthesia. Histopathological examination showed that testicular injury mediated by arsenic was ameliorated by the administration of melatonin. The number of apoptotic germ cell was increased, and the number of proliferating cell nuclear antigen (PCNA)-positive germ cell was decreased in testis after arsenic administration. Our data indicate a significant reduction in the activity of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, and there was a rise in the expression of PCNA in testis of arsenic + melatonin group. The decreased superoxide dismutase, catalase, and glutathione peroxidase activities as well as increased malondialdehyde levels in testis due to arsenic administration were also counteracted by melatonin. These data suggested that melatonin has beneficial effects against arsenic-induced testicular damage by decreasing morphological damage, germ cell apoptosis, lipid peroxidation, and oxidative stress. Our results suggest that melatonin plays a protective role against arsenic-induced testicular apoptosis and oxidative stress. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 5 |
| Journal | Toxicology and Industrial Health |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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