NDLI: Clinicopathological sex- related relevance of musashi1 mRNA expression in esophageal squamous cell carcinoma patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moghbeli, Meysam Forghanifard, Mohammad Mahdi Aarabi, Azadeh Mansourian, Akram Abbaszadegan, Mohammad Reza
Description	Country affiliation: Iran Author Affiliation: Moghbeli M ( Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.)
Abstract	The cancer stem cell theory is considered as the spotlight of cancer biology, in which a subpopulation of tumor cells show unlimited proliferative and self renewal capacities. Post-transcriptional regulation is involved in different cellular functions such as cell differentiation and proliferation which results in cellular diversity. Musashi1 (Msi1) is one of the most important RNA-binding proteins (RBPs) which are involved in translational inhibition. Although, Msi1 targets are largely unknown, p21WAF-1, a cell cycle regulator, and Numb, inhibitor of notch signaling pathway, are well-known factors which are suppressed by the Msi1 in normal and cancer stem cells. Msi1 expression in tumor tissues from 53 ESCC patients was compared to normal tissues using real-time polymerase chain reaction (PCR). Msi1 was significantely overexpressed in 41.5 % of tumor samples and we observed a significant correlation between Msi1 expression and sex, in which the males had shown a higher level of Msi1 expression in comparison with the females (2.00 Vs 0.78 fold changes, p = 0.05). In this study, we assessed whether Msi1 is expressed in ESCC samples suggesting this protein as a novel cancer stem cell marker which requires further studies.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	20
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2014-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Squamous Cell Genetics Esophageal Neoplasms Nerve Tissue Proteins Rna, Messenger Rna-binding Proteins Pathology Cell Differentiation Cell Proliferation Female Humans Male Middle Aged Neoplastic Stem Cells Metabolism Rna Processing, Post-transcriptional Signal Transduction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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