NDLI: Alterations in both the activatory and inhibitory potential of peripheral blood CD4+ T cells in rheumatoid arthritis patients correlate with disease progression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kosmaczewska, Agata Ciszak, Lidia Swierkot, Jerzy Szteblich, Aleksandra Wiland, Piotr Frydecka, Irena
Description	Author Affiliation: Kosmaczewska A ( Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, kosmacz@iitd.pan.wroc.pl.)
Abstract	The chronic nature of rheumatoid arthritis (RA) suggests immune dysfunction, including persistent systemic activation. Therefore, we evaluated the activatory and inhibitory potential as well as proliferative activity of peripheral blood (PB) CD4+ T cells from RA patients in different stages of the disease and after different therapeutic interventions. We found that CD4+ T cells from RA patients were activated in vivo concerning decreased CD28 expression and increase of CD40L, CD69, and CTLA-4 expression; however, the extent of stimulation was suboptimal when compared to healthy controls. Consequently, impaired proliferative activities of these cells were found in all patients irrespective of the active disease duration. Treatment with methotrexate (MTX) and/or inhibitors of TNF-alpha (iTNF) did not significantly influence systemic activation in RA patients, which corresponded with the maintenance of inflammation markers; however, partial restoration of CD28 and CTLA-4 expression as well as clinical improvement were observed. In patients with early disease (the MTX group), we noted higher capacity of CD4+ T cells for restoration of T cell function, whereas cells from the iTNF group with progressive disease remained with a proliferative defect after the treatment. In conclusion, our study demonstrates that the dysregulated expression of molecules interfering with CD4+ T cell signaling may result in functional impairment of the effector T cells and correlates with disease progression.
File Format	HTM / HTML
ISSN	12194956
e-ISSN	15322807
DOI	10.1007/s12253-013-9687-0
Journal	Pathology & Oncology Research
Issue Number	2
Volume Number	20
Language	English
Publisher	Springer
Publisher Date	2014-04-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Oncology Arthritis, Rheumatoid Immunology Pathology Cd4-positive T-lymphocytes Antigens, Cd Drug Therapy Metabolism Biological Markers Drug Effects Ctla-4 Antigen Case-control Studies Cell Proliferation Disease Progression Inflammation Lymphocyte Activation Methotrexate Therapeutic Use Tumor Necrosis Factor-alpha Antagonists & Inhibitors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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