NDLI: Histopathology, humoral and cellular immune response in the murine model of Leishmania (Viannia) shawi.

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Year: 2010 Volume: 59 Issue: 1

Year: 2009 Volume: 58

Histopathology, humoral and cellular immune response in the murine model of Leishmania (Viannia) shawi.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Passero, Luiz Felipe Domingues Marques, Cláudia Vale-Gato, Inês Corbett, Carlos Eduardo Pereira Laurenti, Márcia Dalastra Santos-Gomes, Gabriela
Description	Country affiliation: Brazil Author Affiliation: Passero LF ( Laboratorio Patologia de Moléstias Infecciosas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.)
Abstract	Leishmania (Viannia) shawi was recently characterized and few studies concerning modifications in cellular and humoral immune responses in experimental leishmaniasis have been conducted. In this work, immunopathological changes induced by L. shawi in chronically infected BALB/c mice were investigated. Infected BALB/c mice developed increased lesion size associated with strong inflammatory infiltrate diffusely distributed in the dermis, with highly infected macrophages. The humoral immune response was predominantly directed toward the IgG1 isotype. The functional activity of CD4(+) and CD8(+) T cells showed significantly increased TNF-alpha mRNA levels associated with reduced IFN-gamma expression by CD4(+) T cells and the double negative (dn) CD4CD8 cell subset. High IL-4 levels expressed by CD8(+) T cells and dnCD4CD8 and TGF-beta by CD4(+) and CD8(+) T cells were detected, while IL-10 was highly expressed by all three cell subpopulations. Taken together, these results show an evident imbalance between TNF-alpha and IFN-gamma that is unfavorable to amastigote replication control. Furthermore, L. shawi seems to regulate different cell populations to express deactivating cytokines to avoid its own destruction. This study indicates BALB/c mice as a potentially good experimental model for further studies on American cutaneous leishmaniosis caused by L. shawi.
File Format	HTM / HTML
ISSN	13835769
Issue Number	2
Volume Number	59
e-ISSN	18730329
Journal	Parasitology International
Language	English
Publisher	Elsevier
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Parasitology Antibodies, Protozoan Blood Cd4-positive T-lymphocytes Immunology Cd8-positive T-lymphocytes Disease Models, Animal Leishmania Leishmaniasis, Cutaneous Animals Cytokines Metabolism Dermis Parasitology Pathology Humans Immunoglobulin G Classification Growth & Development Pathogenicity Physiopathology Macrophages Mice Mice, Inbred Balb C Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology

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