NDLI: Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens.

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Year: 2010 Volume: 59 Issue: 1

Year: 2009 Volume: 58

Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vendrametto, Michele Cristina Santos, Adriana Oliveira dos Nakamura, Celso Vataru Dias Filho, Benedito Prado Cortez, Diógenes Aparício Garcia Ueda-Nakamura, Tânia
Description	Country affiliation: Brazil Author Affiliation: Vendrametto MC ( Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Universidade Estadual de Maringá, Av. Colombo 5790, Paraná, Brazil.)
Abstract	Infection with Leishmania spp. causes a disease with multifaceted clinical manifestations in humans. The treatment for leishmaniasis is dependent on a limited range of drugs. Here we investigated the antileishmanial activity of eupomatenoid-5, a neolignan isolated from leaves of Piper regnellii var. pallescens. We showed that eupomatenoid-5 had a dose-dependent activity during 72h of treatment, exhibiting IC(50) of 9.0microg/mL and 13.0microg/mL for promastigote and axenic amastigote forms, respectively, and IC(50) of 5.0microg/mL for intracellular amastigote forms of Leishmania amazonensis. When L. amazonensis was treated with eupomatenoid-5, it underwent considerable ultrastructural alterations, as shown by transmission electron microscopy. Among the alterations was the appearance of intense exocytic activity in the region of the flagellar pocket, myelin-like figures, and vacuoles in the cytoplasm of parasites treated with 9.0microg/mL. Cells treated with 25.0microg/mL showed a very large structure, apparently an extension of the endoplasmic reticulum. Also, mitochondrial swelling was detected at this concentration, indicating damage and significant change in this organelle. A cytotoxicity assay showed that the action of the isolated compound is more specific for protozoa and it is not toxic to macrophages. Our studies indicated that eupomatenoid-5 might be a potential new drug for the treatment of leishmaniasis, because this compound displays interesting antileishmanial activity in vitro against promastigote, axenic amastigote, and intracellular amastigote forms of L. amazonensis.
File Format	HTM / HTML
ISSN	13835769
Issue Number	2
Volume Number	59
e-ISSN	18730329
Journal	Parasitology International
Language	English
Publisher	Elsevier
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Parasitology Antiprotozoal Agents Pharmacology Benzofurans Leishmania Drug Effects Phenols Piper Chemistry Plant Leaves Animals Isolation & Purification Toxicity Cell Line Cells, Cultured Dose-response Relationship, Drug Classification Growth & Development Ultrastructure Leishmaniasis Drug Therapy Parasitology Macrophages Macrophages, Peritoneal Mice Mice, Inbred Balb C Microscopy, Electron, Transmission Parasitic Sensitivity Tests Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology

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Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens.

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