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Year: 2010 Volume: 59 Issue: 1

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A novel DEAD box helicase Has1p from Plasmodium falciparum: N-terminal is essential for activity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Prakash, Krishna Tuteja, Renu
Description	Country affiliation: India Author Affiliation: Prakash K ( Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.)
Abstract	Helicases catalyze the opening of nucleic acid duplexes and are implicated in many nucleic acid metabolic cellular processes that require single stranded DNA or reorganization of RNA structure. Previously we have reported that Plasmodium falciparum genome contains a number of DEAD box helicases. In the present study we report the cloning, expression and characterization of one of the novel members of DEAD box family from P. falciparum. Our results indicate that it is a homologue of Has1p from yeast and it contains DNA and RNA unwinding, nucleic acid-dependent ATPase and RNA binding activities. This enzyme can utilize all the nucleosidetriphosphates (NTPs) and deoxy nucleosidetriphosphates (dNTPs) for its unwinding activity. Using a truncated derivative of this protein we further report that the N-terminal region of the protein is essentially required for its activity. These studies suggest that besides the conserved helicase domain the highly variable N-terminal region also contributes in the activity of the protein.
File Format	HTM / HTML
ISSN	13835769
Issue Number	2
Volume Number	59
e-ISSN	18730329
Journal	Parasitology International
Language	English
Publisher	Elsevier
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Parasitology Dead-box Rna Helicases Plasmodium Falciparum Enzymology Protozoan Proteins Adenosine Triphosphatases Metabolism Amino Acid Sequence Animals Cloning, Molecular Chemistry Genetics Dna, Protozoan Humans Malaria, Falciparum Parasitology Models, Molecular Molecular Sequence Data Rna, Protozoan Sequence Alignment Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology

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