NDLI: Protective effects of 1,3-diaryl-2-propen-1-one derivatives against $H_{2}O_{2}-induced$ damage in SK-N-MC cells

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Protective effects of 1,3-diaryl-2-propen-1-one derivatives against $H_{2}O_{2}-induced$ damage in SK-N-MC cells

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Protective effects of 1,3-diaryl-2-propen-1-one derivatives against $H_{2}O_{2}-induced$ damage in SK-N-MC cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bayati, Samaneh Yazdanparast, Razieh Majd, Soraya Sajadi Oh, Seikwan
Description	Country affiliation: Iran Author Affiliation: Bayati S ( Institute of Biochemistry and Biophysics, PO Box 13145-1384, University of Tehran, Tehran, Iran.)
Abstract	Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the central nervous system resulting in memory loss and dementia. Some of the associated pathogenic changes are amyloid peptide aggregation, excitotoxicity, oxidative stress and inflammation. Oxidative stress plays an indispensable role in the pathophysiology of AD. Therefore, antioxidant therapies appear to be promising approaches in dealing with AD patients. In that line, we evaluated the free radical scavenging capabilities of 13 different chalcones (1,3-diphenyl-2-propen-1-one) derivatives against the free-radical damaging effects of hydrogen peroxide $(H_{2}O_{2})$ on the SK-N-MC neuroblastoma cell line. Pretreatment of the cells for 3 h with 20 µ m of each of these derivatives (compounds 8–20) followed by exposure to 300 µ m $H_{2}O_{2}$ for 24 h indicated that all compounds, except compound 20, were capable of restoring the viabilities of cells relative to the control $(H_{2}O_{2}–treated)$ cells. The destructive effect of $H_{2}O_{2}$ on the adhesive behavior of the cells was almost totally restored by each of the derivatives. In addition, each of the derivatives except compounds 20 and 14 significantly reduced the extent of lipofuscin formation among the cells time-dependently. Despite these activities, some of the derivatives, such as compounds 12 and 19, did not reduce the $H_{2}O_{2}-induced$ intracellular ROS (reactive oxygen species) levels, meaning that these two derivatives act through a different mechanism other than free-radical scavenging activity. On the other hand, for those derivatives acting as anti-oxidants, structure–activity evaluation clearly revealed that the hydroxyl group of vanillin ring is required for their free-radical scavenging activities. Copyright © 2010 John Wiley & Sons, Ltd.
File Format	HTM / HTML
ISSN	0260437X
Issue Number	6
Volume Number	31
e-ISSN	10991263
Journal	Journal of Applied Toxicology
Language	English
Publisher	Wiley
Publisher Date	2011-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Free Radical Scavengers Pharmacology Hydrogen Peroxide Toxicity Propane Analogs & Derivatives Alzheimer Disease Drug Therapy Physiopathology Antioxidants Apoptosis Drug Effects Cell Line, Tumor Cell Survival Humans Oxidative Stress Reactive Oxygen Species Metabolism Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Toxicology

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