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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Xuezhen Ji, Wei Zhang, Huan Zhang, Wei Xie, Ping |
| Description | Author Affiliation: Zhang X ( Fisheries College of Huazhong Agricultural University) |
| Abstract | It is well known that fish have stronger tolerance than mammals to microcystin (MC) exposure, and such a difference is attributed to their different core body temperatures. However, no in vivo study has been conducted to investigate the effects of temperature on MC-induced toxicity in fish, a typical poikilotherm. Tolerance and detoxification response of zebrafish treated with MC-LR were investigated under three temperatures. The LD50 values evidently increased with a decline of the temperature (547, 260 and 176 µg kgâ »¹ at 12, 22 and 32 °C, respectively), indicating stronger tolerance of the fish at lower temperatures. Changes in the transcription of glutathione S-transferase (GST) isoforms in the fish were observed, and their sensitivity of response in the transcription of GST mRNA was on the order of 12 > 32 > 22°C. We screened out several GST genes which were more delicate to solve the MC-LR exposure at different temperatures, i.e. GST rho1, al, p1 and theta1 in the 12 °C group, and GST zeta1 and p2 in the 22 and 32 °C groups. Our findings partly validate the hypothesis that high temperature enhances toxic effects of MCs on poikilotherms. Our studies also indicate that temperature-dependent toxic effects should be taken into account for field toxic assessment of microcystins in fish. |
| File Format | HTM / HTML |
| ISSN | 0260437X |
| Issue Number | 6 |
| Volume Number | 31 |
| e-ISSN | 10991263 |
| Journal | Journal of Applied Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Microcystins Toxicity Temperature Zebrafish Animals Glutathione Transferase Genetics Metabolism Lethal Dose 50 Male Oxidative Stress Drug Effects Toxicity Tests Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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