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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bidinotto, Lucas T. Costa, Celso A. R. A. Salvadori, Daisy M. F. Costa, Mirtes Rodrigues, Maria A. M. Barbisan, Luís F. |
| Description | Country affiliation: Brazil Author Affiliation: Bidinotto LT ( Instituto de Biociências, UNESP-Univ. Estadual Paulista, Departamento de Morfologia, 18618-970, Botucatu, SP, Brazil) |
| Abstract | This study investigated the protective effect of oral treatment with lemongrass (Cymbopogon citratus STAPF) essential oil (LGEO) on leukocyte DNA damage induced by N-methyl-N-nitrosurea (MNU). Also, the anticarcinogenic activity of LGEO was investigated in a multi-organ carcinogenesis bioassay induced by 7,12-dimethylbenz(a)antracene, 1,2-dimethylhydrazine and N-butyl-N-(4-hydroxibuthyl)nitrosamine in Balb/C female Balb/c mice (DDB-initiated mice). In the short-term study, the animals were allocated into three groups: vehicle group (negative control), MNU group (positive control) and LGEO 500 mg kgâ »¹ (five times per week for 5 weeks) plus MNU group (test group). Blood samples were collected to analyze leukocyte DNA damage by comet assay 4 h after each MNU application at the end of weeks 3 and 5. The LGEO 500 mg kgâ »¹ treated group showed significantly lower (P < 0.01) leukocyte DNA damage than its respective positive group exposed to MNU alone at week 3. In the medium-term study, DDB-initiated mice were allocated into three groups: vehicle group (positive control) and LGEO 125 or 500 mg kgâ »¹ (five times per week for 6 weeks; test groups). At week 20, all animals were euthanized and mammary glands, colon and urinary bladder were processed for histopathological analyses for detection of preneoplastic and neoplastic lesions. A slight non-significant effect of treatment with LGEO 500 mg kgâ »¹ in reducing development of alveolar and ductal mammary hyperplasia was found (P = 0.075). Our findings indicate that lemongrass essential oil provided protective action against MNU-induced DNA damage and a potential anticarcinogenic activity against mammary carcinogenesis in DDB-initiated female Balb/C mice. |
| File Format | HTM / HTML |
| ISSN | 0260437X |
| Issue Number | 6 |
| Volume Number | 31 |
| e-ISSN | 10991263 |
| Journal | Journal of Applied Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Carcinogenesis Drug Effects Carcinogens Toxicity Dna Damage Plant Oils Pharmacology Terpenes Animals Carcinogenicity Tests Colon Metabolism Comet Assay Endpoint Determination Female Gas Chromatography-mass Spectrometry Mammary Glands, Animal Methylnitrosourea Mice Mice, Inbred Balb C Urinary Bladder Pathology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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