NDLI: Water-soluble lipophilic MR contrast agents for cell membrane labeling.

Please wait, while we are loading the content...

On the interaction of Helicobacter pylori NikR, a Ni(II)-responsive transcription factor, with the urease operator: in solution and in silico studies.

Water-soluble lipophilic MR contrast agents for cell membrane labeling.

Effects of background anionic compounds on the activity of the hammerhead ribozyme in $Mg^{2+}-unsaturated$ solutions

Exploring the copper(II)-aminotriazole complex-binding sites of human serum albumin.

Functional implications of the interaction between HscB and IscU in the biosynthesis of FeS clusters.

Mechanistic information on the nitrite-controlled reduction of aquacob(III)alamin by ascorbate at physiological pH.

Year: 2015 Volume: 20 Issue: 5

Year: 2015 Volume: 20 Issue: 4

Year: 2015 Volume: 20 Issue: 3

Year: 2015 Volume: 20 Issue: 2

Year: 2015 Volume: 20 Issue: 1

Year: 2014 Volume: 19

Year: 2013 Volume: 18

Year: 2012 Volume: 17

Year: 2011 Volume: 16

Year: 2010 Volume: 15

Year: 2009 Volume: 14

Year: 2008 Volume: 13

Year: 2007 Volume: 12

Year: 2005 Volume: 10

Water-soluble lipophilic MR contrast agents for cell membrane labeling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carney, Christiane E. MacRenaris, Keith W. Meade, Thomas J.
Description	Country affiliation: United States Author Affiliation: Carney CE ( Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.)
Abstract	Long-term cell tracking using MR imaging necessitates the development of contrast agents that both label and are retained by cells. One promising strategy for long-term cell labeling is the development of lipophilic Gd(III)-based contrast agents that anchor into the cell membrane. We have previously reported the efficacy of monomeric and multimeric lipophilic agents and showed that the monomeric agents have improved labeling and contrast enhancement of cell populations. Here, we report on the synthesis, characterization, and in vitro testing of a series of monomeric lipophilic contrast agents with varied alkyl chain compositions. We show that these agents disperse in water, localize to the cell membrane, and label HeLa and MCF7 cells effectively. Additionally, these agents have up to tenfold improved retention in cells compared to clinically available ProHance(®).
File Format	HTM / HTML
ISSN	09498257
e-ISSN	14321327
DOI	10.1007/s00775-015-1280-4
Journal	JBIC Journal of Biological Inorganic Chemistry
Issue Number	6
Volume Number	20
Language	English
Publisher	Springer
Publisher Date	2015-09-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Cell Membrane Metabolism Contrast Media Chemical Synthesis Coordination Complexes Gadolinium Chemistry Toxicity Hela Cells Mcf-7 Cells Magnetic Resonance Imaging Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Water-soluble lipophilic MR contrast agents for cell membrane labeling

A multimeric MR-optical contrast agent for multimodal imaging.

Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

Enhanced relaxivity of $Gd^{3+}-based$ contrast agents geometrically confined within porous nanoconstructs

Exploring the cellular accumulation of metal complexes.

Discovery of a strongly apoptotic ruthenium complex through combinatorial coordination chemistry

Cell Labeling via Membrane-Anchored Lipophilic MR Contrast Agents

Cell Labeling via Membrane-Anchored Lipophilic MR Contrast Agents

Preparation of Highly Efficient MRI Contrast Agents through Complexation of Cationic $Gd^{III}-Containing$ Metallosurfactant with Biocompatible Polyelectrolytes

Water-soluble lipophilic MR contrast agents for cell membrane labeling.

Similar Documents

Water-soluble lipophilic MR contrast agents for cell membrane labeling

A multimeric MR-optical contrast agent for multimodal imaging.

Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

Enhanced relaxivity of $Gd^{3+}-based$ contrast agents geometrically confined within porous nanoconstructs

Exploring the cellular accumulation of metal complexes.

Discovery of a strongly apoptotic ruthenium complex through combinatorial coordination chemistry

Cell Labeling via Membrane-Anchored Lipophilic MR Contrast Agents

Cell Labeling via Membrane-Anchored Lipophilic MR Contrast Agents

Preparation of Highly Efficient MRI Contrast Agents through Complexation of Cationic $Gd^{III}-Containing$ Metallosurfactant with Biocompatible Polyelectrolytes

Water-soluble lipophilic MR contrast agents for cell membrane labeling.