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DNA binding and cleavage studies of copper(II) complexes with 2'-deoxyadenosine modified histidine moiety.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Borowska, Justyna Sierant, Malgorzata Sochacka, Elzbieta Sanna, Daniele Lodyga-Chruscinska, Elzbieta
Description	Author Affiliation: Borowska J ( Institute of General Food Chemistry, Lodz University of Technology, ul. Stefanowskiego 4/10, 90-924, Lodz, Poland, juustyna.pawlak@o2.pl.)
Abstract	This work is focused on the study of DNA binding and cleavage properties of 2'-deoxyadenosines modified with ester/amide of histidine (his(6)dA ester, his(6)dA amide) and their copper(II) complexes. To determine the coordination mode of the complex species potentiometric and spectroscopic (UV-visible, CD, EPR) studies have been performed. The analysis of electronic absorption and fluorescence spectra has been used to find the nature of the interactions between the compounds and calf thymus DNA (CT-DNA). There is significant influence of the -NH2 and -OCH3 groups on binding of the ligands or the complexes to DNA. Only amide derivative and its complex reveal intercalative ability. In the case of his(6)dA ester and Cu(II)-his(6)dA ester the main interactions can be groove binding. DNA cleavage activities of the compounds have been examined by gel electrophoresis. The copper complexes have promoted the cleavage of plasmid DNA, but none of the ligands exhibited any chemical nuclease activity. The application of different scavengers of reactive oxygen species provided a conclusion that DNA cleavage caused by copper complexes might occur via hydrolytic pathway.
File Format	HTM / HTML
ISSN	09498257
Issue Number	6
Volume Number	20
e-ISSN	14321327
Journal	JBIC Journal of Biological Inorganic Chemistry
Language	English
Publisher	Springer
Publisher Date	2015-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Coordination Complexes Chemistry Dna Cleavage Dna Deoxyadenosines Histidine Analogs & Derivatives Intercalating Agents Copper Plasmids Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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DNA binding and cleavage studies of copper(II) complexes with 2′-deoxyadenosine modified histidine moiety

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