NDLI: Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bertrand, Benoît Citta, Anna Franken, Inge L. Picquet, Michel Folda, Alessandra Scalcon, Valeria Rigobello, Maria Pia Le Gendre, Pierre Casini, Angela Bodio, Ewen
Description	Country affiliation: France Author Affiliation: Bertrand B ( Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France.)
Abstract	While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or industrial syntheses, their potential to form transition metal complexes for medicinal applications has still to be exploited. Within this frame, we synthesized new homo- and heterobimetallic complexes based on the Au(I)-NHC scaffold. The compounds were synthesized via a microwave-assisted method developed in our laboratories using Au(I)-NHC complexes carrying a pentafluorophenol ester moiety and another Au(I) phosphane complex or a bipyridine ligand bearing a pendant amine function. Thus, we developed two different methods to prepare homo- and heterobimetallic complexes (Au(I)/Au(I) or Au(I)/Cu(II), Au(I)/Ru(II), respectively). All the compounds were fully characterized by several spectroscopic techniques including far infrared, and were tested for their antiproliferative effects in a series of human cancer cells. They showed moderate anticancer properties. Their toxic effects were also studied ex vivo using the precision-cut tissue slices (PCTS) technique and initial results concerning their reactivity with the seleno-enzyme thioredoxin reductase were obtained.
File Format	HTM / HTML
ISSN	09498257
Issue Number	6
Volume Number	20
e-ISSN	14321327
Journal	JBIC Journal of Biological Inorganic Chemistry
Language	English
Publisher	Springer
Publisher Date	2015-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Antineoplastic Agents Chemical Synthesis Therapeutic Use Enzyme Inhibitors Organogold Compounds Thioglucosides Animals Cell Line, Tumor Copper Glutathione Reductase Antagonists & Inhibitors Humans Rats Saccharomyces Cerevisiae Saccharomyces Cerevisiae Proteins Thioredoxin Reductase 1 Thioredoxin Reductase 2 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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