NDLI: Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

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Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Klemm, Piper J. Floyd, William C. Smiles, Danil E. Fréchet, Jean M. J. Raymond, Kenneth N.
Description	Country affiliation: United States Author Affiliation: Klemm PJ ( Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.)
Abstract	Commercial gadolinium magnetic resonance imaging (MRI) contrast agents are limited by low relaxivity (r1) and coordination to only a single water molecule (q = 1). Consequently, gram quantities of these agents must be injected to obtain sufficient diagnostic contrast. In this study, MRI contrast agents for T(1) and T2 relaxivity were synthesized using hydroxypyridinone and terephthalamide chelators with mesityl and 1,4,7-triazacyclononane capping moieties. When covalently conjugated to a highly biocompatible esteramide dendrimer, T2 relaxation rates up to 52 mm(-1) s(-1) and T1 relaxation rates up to 31 mm(-1) s(-1) per gadolinium were observed under clinically relevant conditions. These values are believed to be brought about by using a dendritic macromolecule to decrease the molecular tumbling time of the small molecule complexes. These agents also show high aqueous solubility and low toxicity in vitro. In this study we report six new compounds: three discrete complexes and three dendrimer conjugates.
File Format	HTM / HTML
ISSN	15554309
e-ISSN	15554317
DOI	10.1002/cmmi.483
Journal	Contrast Media & Molecular Imaging
Issue Number	1
Volume Number	7
Language	English
Publisher	Wiley
Publisher Date	2012-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Diagnostic Imaging Contrast Media Chemical Synthesis Dendrimers Gadolinium Chemistry Heterocyclic Compounds Magnetic Resonance Imaging Pyridones Toxicity Coordination Complexes Hela Cells Drug Effects Molecular Structure Protons Solubility Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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Improving T1 and T2 magnetic resonance imaging (MRI) contrast agents through the conjugation of an esteramide dendrimer to high water coordination Gd(III) hydroxypyridinone (HOPO) complexes

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