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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sreekanth, B. Krishnamurthy, G. Naik, H. S. Bhojya Vishnuvardhan, T. K. |
| Description | Country affiliation: India Author Affiliation: Sreekanth B ( Department of Biotechnology, Acharya Institute of Technology, Bangalore, Karnataka, India.) |
| Abstract | The two new metal complexes of Cu(II) and Mn(II) containing macroacyclic ligand of the type [Cu(hpn)](PF(6))(2) (1) and [Mn(hpn)](PF(6))(2) (2) [where hpn = [1-{[2-{[2-hydroxynaphthalen-1-yl)methylidine]amino}phenyl)imino]methyl}naphthalene-2-ol]] have been synthesized and characterized by employing analytical and spectral methods. The DNA binding properties of the complexes with calf thymus-DNA were studied by using absorption spectra and viscosity measurements, as well as thermal denaturation experiments. The absorption spectra indicated that the complexes intercalate tightly between the base pairs of the DNA with intrinsic DNA binding constants of 1.8 × 10(4) M(-1) for (1) and 3.7 × 10(4) M(-1) for (2) in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, respectively. The enhancement in the relative viscosity of DNA on binding to the ligand supports the proposed DNA binding modes. The oxidative cleavage activity of complexes (1) and (2) were carried out on double-stranded pUC19 circular plasmid DNA using gel electrophoresis. The complexes show significant nuclease activity. |
| File Format | HTM / HTML |
| ISSN | 15257770 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 15322335 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Coordination Complexes Chemical Synthesis Dna Cleavage Deoxyribonucleases Intercalating Agents Naphthalenes Animals Binding Sites Biomimetics Cattle Chemistry Pharmacology Copper Dna Dna, Circular Electrophoresis, Agar Gel Ligands Manganese Oxidation-reduction Spectrum Analysis Viscosity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Medicine |
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