NDLI: Combining Monte Carlo methods with coherent wave optics for the simulation of phase-sensitive X-ray imaging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peter, Silvia Modregger, Peter Fix, Michael K. Volken, Werner Frei, Daniel Manser, Peter Stampanoni, Marco
Description	Country affiliation: Switzerland Author Affiliation: Peter S ( Swiss Light Source, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.); Modregger P ( Swiss Light Source, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.); Fix MK ( Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, University Hospital Bern and University of Bern, CH-3010 Bern, Switzerland.); Volken W ( Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, University Hospital Bern and University of Bern, CH-3010 Bern, Switzerland.); Frei D ( Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, University Hospital Bern and University of Bern, CH-3010 Bern, Switzerland.); Manser P ( Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, University Hospital Bern and University of Bern, CH-3010 Bern, Switzerland.); Stampanoni M ( Swiss Light Source, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.)
Abstract	Phase-sensitive X-ray imaging shows a high sensitivity towards electron density variations, making it well suited for imaging of soft tissue matter. However, there are still open questions about the details of the image formation process. Here, a framework for numerical simulations of phase-sensitive X-ray imaging is presented, which takes both particle- and wave-like properties of X-rays into consideration. A split approach is presented where we combine a Monte Carlo method (MC) based sample part with a wave optics simulation based propagation part, leading to a framework that takes both particle- and wave-like properties into account. The framework can be adapted to different phase-sensitive imaging methods and has been validated through comparisons with experiments for grating interferometry and propagation-based imaging. The validation of the framework shows that the combination of wave optics and MC has been successfully implemented and yields good agreement between measurements and simulations. This demonstrates that the physical processes relevant for developing a deeper understanding of scattering in the context of phase-sensitive imaging are modelled in a sufficiently accurate manner. The framework can be used for the simulation of phase-sensitive X-ray imaging, for instance for the simulation of grating interferometry or propagation-based imaging.
File Format	HTM / HTML
ISSN	09090495
e-ISSN	16005775
DOI	10.1107/S1600577514000952
Journal	Journal of Synchrotron Radiation
Issue Number	Pt 3
Volume Number	21
Language	English
Publisher	IUCr
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Radiology
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Instrumentation Radiation

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