NDLI: Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cornelius, Iwan Guatelli, Susanna Fournier, Pauline Crosbie, Jeffrey C. Sanchez Del Rio, Manuel Bräuer-Krisch, Elke Rosenfeld, Anatoly Lerch, Michael
Description	Country affiliation: Australia Author Affiliation: Cornelius I ( Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.); Guatelli S ( Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.); Fournier P ( Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.); Crosbie JC ( Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria 3152, Australia.); Sanchez Del Rio M ( European Synchrotron Radiation Facility, Grenoble, France.); Bräuer-Krisch E ( European Synchrotron Radiation Facility, Grenoble, France.); Rosenfeld A ( Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.); Lerch M ( Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.)
Abstract	Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.
File Format	HTM / HTML
ISSN	09090495
Issue Number	Pt 3
Journal	Journal of Synchrotron Radiation
Volume Number	21
e-ISSN	16005775
Language	English
Publisher	IUCr
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Radiology
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Instrumentation Radiation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in