NDLI: Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kraft, Robert Herndon, David N. Finnerty, Celeste C. Cox, Robert A. Song, Juquan Jeschke, Marc G.
Description	Country affiliation: Canada Author Affiliation: Kraft R ( *Shriners Hospitals for Children, and Department of Surgery, Shriners Hospitals for Children)
Abstract	The inflammatory response induced by burn injury contributes to increased incidence of infections, sepsis, organ failure, and mortality. Thus, monitoring postburn inflammation is of paramount importance but, so far, there are no reliable biomarkers available to monitor and/or predict infectious complications after burn. As interleukin 8 (IL-8) is a major mediator for inflammatory responses, the aim of our study was to determine whether IL-8 expression can be used to predict postburn sepsis, infections, and mortality. Plasma cytokines, acute-phase proteins, constitutive proteins, and hormones were analyzed during the first 60 days after injury from 468 pediatric burn patients. Demographics and clinical outcome variables (length of stay, infection, sepsis, multiorgan failure [MOF], and mortality) were recorded. A cutoff level for IL-8 was determined using receiver operating characteristic analysis. Statistical significance is set at P < 0.05. Receiver operating characteristic analysis identified a cutoff level of 234 pg/mL for IL-8 for survival. Patients were grouped according to their average IL-8 levels relative to this cutoff and stratified into high (H) (n = 133) and low (L) (n = 335) groups. In the L group, regression analysis revealed a significant predictive value of IL-8 to percent of total body surface area burned and incidence of MOF (P < 0.001). In the H group, IL-8 levels were able to predict sepsis (P < 0.002). In the H group, elevated IL-8 was associated with increased inflammatory and acute-phase responses compared with the L group (P < 0.05). High levels of IL-8 correlated with increased MOF, sepsis, and mortality. These data suggest that serum levels of IL-8 may be a valid biomarker for monitoring sepsis, infections, and mortality in burn patients.
File Format	HTM / HTML
ISSN	10732322
e-ISSN	15400514
DOI	10.1097/SHK.0000000000000294
Journal	Shock
Issue Number	3
Volume Number	43
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2015-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Intensive care medicine Burns Blood Complications Infection Etiology Interleukin-8 Sepsis Adolescent Biological Markers Mortality Child, Preschool Inflammation Mediators Kaplan-meier Estimate Multiple Organ Failure Predictive Value Of Tests Prospective Studies Clinical Trial Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine Critical Care and Intensive Care Medicine

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