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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Jingyao Pang, Qing Song, Sidong Zhang, Ruiyao Liu, Sushun Huang, Zichao Wu, Qifei Liu, Yang Liu, Chang |
| Description | Author Affiliation: Zhang J ( Departments of *Hepatobiliary Surgery and Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University) |
| Abstract | Zymosan-induced multiple organ dysfunction syndrome (MODS) is a multifactorial pathology that involves the deterioration of function of several organs. 5-Hydroxytryptamine (5-HT) is a small monoamine molecule that is primarily known for its role as a neurotransmitter. Previous studies have shown that 5-HT could serve as an important inflammatory mediator in the peripheral immune system. In the present study, we investigated the effect of 5-HT on the development of non-septic shock caused by zymosan in mice. Tryptophan hydroxylase 1-knockout mice (TPH1, leading to the absence of 5-HT), TPH1 + 5-hydroxytryptophan (precursor of 5-HT) treatment mice, wild-type (TPH1) mice, and wild-type plus p-chlorophenylalanine (PCPA, TPH1 inhibitor) treatment mice received zymosan intraperitoneally at a dose of 500 mg/kg. Organ failure and systemic inflammation in the mice were assessed 18 h after the administration of zymosan. Deficiency of 5-HT caused a significant reduction of the 1) peritoneal exudate formation, 2) neutrophil infiltration, 3) MODS, 4) nitrosative stress, and 5) cytokine formation. In addition, at the end of the observation period (7 days), deficiency of 5-HT in the mice was shown to be able to alleviate the severe illness characterized as systemic toxicity, significant loss of body weight, and high mortality caused by zymosan. In conclusion, the lack of 5-HT by genetic knockout or by pharmacologic inhibition of the TPH1 enzyme significantly attenuated zymosan-induced MODS. |
| File Format | HTM / HTML |
| ISSN | 10732322 |
| Issue Number | 3 |
| Volume Number | 43 |
| e-ISSN | 15400514 |
| Journal | Shock |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2015-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Intensive care medicine Multiple Organ Failure Prevention & Control Serotonin Physiology 5-hydroxytryptophan Administration & Dosage Animals Cytokines Biosynthesis Disease Models, Animal Enzyme Inhibitors Fenclonine Male Mice Mice, Inbred C57bl Mice, Knockout Etiology Physiopathology Oxidative Stress Peritonitis Pathology Protective Agents Deficiency Shock Complications Tryptophan Hydroxylase Antagonists & Inhibitors Genetics Zymosan Toxicity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
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