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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hayakawa, Mineji Gando, Satoshi Ono, Yuichi Wada, Takeshi Yanagida, Yuichiro Sawamura, Atsushi Ieko, Masahiro |
| Description | Country affiliation: Japan Author Affiliation: Hayakawa M ( *Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo) |
| Abstract | BACKGROUND: There are two opposing possibilities for the main pathogenesis of trauma-induced coagulopathy: an acute coagulopathy of trauma shock and disseminated intravascular coagulation with the fibrinolytic phenotype. OBJECTIVE: The objective of this study was to clarify the main pathogenesis of trauma-induced coagulopathy using a rat model of Noble-Collip drum trauma. METHODS: Eighteen rats were divided into the control, trauma 0, and trauma 30 groups. The trauma 0 and 30 groups were exposed to Noble-Collip drum trauma. Blood samples were drawn without, immediately after, and 30 min after Noble-Collip drum trauma in the control, trauma 0, and trauma 30 groups, respectively. Coagulation and fibrinolysis markers were measured. Thrombin generation was assessed according to a calibrated automated thrombogram. RESULTS: Spontaneous thrombin bursts resulting from circulating procoagulants were observed in the nonstimulated thrombin generation assay immediately after trauma. Soluble fibrin levels (a marker of thrombin generation in the systemic circulation) were 50-fold greater in the trauma groups than in the control group. The resultant coagulation activation consumed platelets, coagulation factors, and antithrombin. Endogenous thrombin potential and factor II ratio were significantly negatively correlated with antithrombin levels, suggesting insufficient control of thrombin generation by antithrombin. High levels of active tissue-type plasminogen activator induced hyperfibrin(ogen)olysis. Soluble thrombomodulin increased significantly. However, activated protein C levels did not change. CONCLUSIONS: The systemic thrombin generation accelerated by insufficient antithrombin control leads to the consumption of platelets and coagulation factors associated with hyperfibrin(ogen)olysis. These changes are collectively termed disseminated intravascular coagulation with the fibrinolytic phenotype. |
| File Format | HTM / HTML |
| ISSN | 10732322 |
| Issue Number | 3 |
| Volume Number | 43 |
| e-ISSN | 15400514 |
| Journal | Shock |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2015-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Intensive care medicine Blood Coagulation Disorders Etiology Disseminated Intravascular Coagulation Shock, Traumatic Complications Animals Blood Disease Models, Animal Fibrin Fibrinogen Degradation Products Metabolism Fibrinolysis Male Phenotype Rats Rats, Wistar Thrombin Biosynthesis Tissue Plasminogen Activator Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
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