NDLI: Cardiopulmonary Arrest and Resuscitation in Severe Sepsis and Septic Shock: A Research Model.

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Cardiopulmonary Arrest and Resuscitation in Severe Sepsis and Septic Shock: A Research Model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chalkias, Athanasios Spyropoulos, Vaios Koutsovasilis, Anastasios Papalois, Apostolos Kouskouni, Evaggelia Xanthos, Theodoros
Description	Country affiliation: Greece Author Affiliation: Chalkias A ( *National and Kapodistrian University of Athens, Medical School, MSc 'Cardiopulmonary Resuscitation')
Abstract	Cardiopulmonary resuscitation in patients with severe sepsis and septic shock is challenging and usually unsuccessful. The aim of the present study is to describe our swine model of cardiac arrest and resuscitation in severe sepsis and septic shock. In this prospective randomized animal study, 10 healthy female Landrace-Large White pigs with an average weight of 20 ± 1 kg (aged 19 - 21 weeks) were the study subjects. Septicemia was induced by an intravenous infusion of a bolus of 20-mL bacterial suspension in 2 min, followed by a continuous infusion during the rest of the experiment. After septic shock was confirmed, the animals were left untreated until cardiac arrest occurred. All animals developed pulseless electrical activity between the fifth and sixth hours of septicemia, whereas five (50%) of 10 animals were successfully resuscitated. Coronary perfusion pressure was statistically significantly different between surviving and nonsurviving animals. We found a statistically significant correlation between mean arterial pressure and unsuccessful resuscitation (P = 0.046), whereas there was no difference in end-tidal carbon dioxide (23.05 ± 1.73 vs. 23.56 ± 1.70; P = 0.735) between animals with return of spontaneous circulation and nonsurviving animals. During the 45-min postresuscitation monitoring, we noted a significant decrease in hemodynamic parameters, although oxygenation indices and lactate clearance were constantly increased (P = 0.001). This successful basic swine model was for the first time developed and may prove extremely useful in future studies on the periarrest period in severe sepsis and septic shock.
File Format	HTM / HTML
ISSN	10732322
Issue Number	3
Volume Number	43
e-ISSN	15400514
Journal	Shock
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2015-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Intensive care medicine Cardiopulmonary Resuscitation Methods Heart Arrest Etiology Therapy Sepsis Complications Shock, Septic Animals Disease Models, Animal Female Physiopathology Hemodynamics Oxygen Blood Sus Scrofa Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine Critical Care and Intensive Care Medicine

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