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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhao, Shengli Ting, Jonathan T. Atallah, Hisham E. Qiu, Li Tan, Jie Gloss, Bernd Augustine, George J. Deisseroth, Karl Luo, Minmin Graybiel, Ann M. Feng, Guoping |
| Description | Country affiliation: United States Author Affiliation: Zhao S ( Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.) |
| Abstract | Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of channelrhodopsin-2, ChR2(H134R), under the control of cell typespecific promoter elements. We performed an extensive functional characterization of the newly established VGAT-ChR2(H134R)-EYFP, ChAT-ChR2(H134R)-EYFP, Tph2-ChR2(H134R)-EYFP and Pvalb(H134R)-ChR2-EYFP BAC transgenic mouse lines and demonstrate the utility of these lines for precisely controlling action-potential firing of GABAergic, cholinergic, serotonergic and parvalbumin-expressing neuron subsets using blue light. This resource of cell typespecific ChR2(H134R) mouse lines will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior. |
| File Format | HTM / HTML |
| ISSN | 15487091 |
| e-ISSN | 15487105 |
| Journal | Nature Methods |
| Issue Number | 9 |
| Volume Number | 8 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2011-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Clinical Laboratory Techniques Mice, Transgenic Neurons Physiology Rhodopsin Genetics Action Potentials Animals Choline O-acetyltransferase Chromosomes, Artificial, Bacterial Hippocampus Cytology Mice Nerve Tissue Tryptophan Hydroxylase Vesicular Inhibitory Amino Acid Transport Proteins Research Support, American Recovery And Reinvestment Act Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology Biotechnology |
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