NDLI: An informatic framework for decoding protein complexes by top-down mass spectrometry.

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An informatic framework for decoding protein complexes by top-down mass spectrometry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Skinner, Owen S. Havugimana, Pierre C. Haverland, Nicole A. Fornelli, Luca Early, Bryan P. Greer, Joseph B. Fellers, Ryan T. Durbin, Kenneth R. Do Vale, Luis H. F. Melani, Rafael D. Seckler, Henrique S. Nelp, Micah T. Belov, Mikhail E. Horning, Stevan R. Makarov, Alexander A. LeDuc, Richard D. Bandarian, Vahe Compton, Philip D. Kelleher, Neil L.
Description	Country affiliation: United States Author Affiliation: Skinner OS ( Department of Chemistry, Northwestern University, Evanston, Illinois, USA.); Havugimana PC ( Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.); Haverland NA ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Fornelli L ( Department of Chemistry, Northwestern University, Evanston, Illinois, USA.); Early BP ( Department of Chemistry, Northwestern University, Evanston, Illinois, USA.); Greer JB ( Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.); Fellers RT ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Durbin KR ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Do Vale LH ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Melani RD ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Seckler HS ( Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.); Nelp MT ( Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.); Belov ME ( Brazilian Center for Protein Research, University of Brasilia, Brasilia, Federal District, Brazil.); Horning SR ( Department of Chemistry, Northwestern University, Evanston, Illinois, USA.); Makarov AA ( Department of Chemistry, Northwestern University, Evanston, Illinois, USA.); LeDuc RD ( Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.); Bandarian V ( Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany.); Compton PD ( Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany.); Kelleher NL ( Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany.)
Abstract	Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we report a computational search strategy that supports hierarchical top-down analysis for precise identification and scoring of multi-proteoform complexes by native mass spectrometry.
File Format	HTM / HTML
ISSN	15487091
e-ISSN	15487105
DOI	10.1038/nmeth.3731
Journal	Nature Methods
Issue Number	3
Volume Number	13
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Clinical Laboratory Techniques Data Mining Databases, Protein Mass Spectrometry Protein Interaction Mapping Proteome Metabolism Sequence Analysis, Protein Algorithms Amino Acid Sequence Binding Sites Computer Simulation Models, Chemical Molecular Sequence Data Protein Binding Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Biotechnology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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