NDLI: Immune evasion strategies of trypanosomes: a review.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oladiran, Ayoola Belosevic, Miodrag
Description	Country affiliation: Canada Author Affiliation: Oladiran A ( Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.)
Abstract	Trypanosomes are digenetic protozoans that infect domestic and wild animals, as well as humans. They cause important medical and veterinary diseases, making them a major public health concern. There are many species of trypanosomes that infect virtually all vertebrate taxa. They typically cycle between insect or leech vectors and vertebrate hosts, and they undergo biochemical and morphological changes in the process. Trypanosomes have received much attention in the last 4 decades because of the diseases they cause and their remarkable armamentarium of immune evasion mechanisms. The completed genome sequences of trypanosomes have revealed an extensive array of molecules that contribute to various immune evasion mechanisms. The different species interact uniquely with their vertebrate hosts with a wide range of evasion strategies and some of the most fascinating immune evasion mechanisms, including antigenic variation that was first described in the trypanosomes. This review focuses on the variety of strategies that these parasites have evolved to evade or modulate immunity of endothermic and ectothermic vertebrates.
File Format	HTM / HTML
ISSN	00223395
Issue Number	2
Volume Number	98
e-ISSN	19372345
Journal	Journal of Parasitology
Language	English
Publisher	American Society of Parasitologists
Publisher Date	2012-04-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Parasitology Immune Evasion Physiology Mammals Parasitology Trypanosoma Immunology Trypanosomiasis Animals Host-parasite Interactions Humans Invertebrates Life Cycle Stages Vertebrates Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Medicine Parasitology Ecology, Evolution, Behavior and Systematics

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