NDLI: Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Chung-Kwe Chen, Lih-Geeng Wen, Chi-Luan Hou, Wen-Chi Hung, Ling-Fang Yen, Shish-Jung Shen, Yi-Jyun Lin, Shyr-Yi Liang, Yu-Chih
Description	Country affiliation: Taiwan Author Affiliation: Wang CK ( Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan.)
Abstract	Vitis thunbergii var. taiwaniana (VTT) is a wild grape native to Taiwan, where it has been used as a folk medicine. In this study, we found that the branch and leaf ethanol extracts of VTT significantly inhibited the inducible nitric oxide (NO) synthase protein expression and NO production in BV2 microglia. Using primary neuronal cells, kainic acid (KA) significantly increased hydrogen peroxide production in a dose-dependent manner. All four ethanol extracts of VTT significantly decreased hydrogen peroxide production. However, only root and branch ethanol extracts were able to prevent the neuronal cell death induced by KA in vitro. In the animal study, administration of all four plant part extracts of VTT delayed the onset of seizure and decreased the hippocampus neuronal cell loss, and the neuroprotective activity could be ranked as follows: branch approximately leaf > root > trunk. The results suggest that VTT extracts have a potential to prevent neurodegeneration through the antioxidative activity by their ability to inhibit NO and hydrogen peroxide production.
File Format	HTM / HTML
ISSN	1096620X
Issue Number	1
Volume Number	13
e-ISSN	15577600
Journal	Journal of Medicinal Food
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Antioxidants Therapeutic Use Hippocampus Drug Effects Microglia Neuroprotective Agents Plant Extracts Seizures Drug Therapy Vitis Animals Pharmacology Cell Death Cell Line Hydrogen Peroxide Antagonists & Inhibitors Kainic Acid Male Mice Mice, Inbred C57bl Neurons Nitric Oxide Nitric Oxide Synthase Type Ii Oxidative Stress Phytotherapy Plant Leaves Plant Stems Rats Rats, Sprague-dawley Chemically Induced Metabolism Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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