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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Koenig, Steven M. Ostrom, Nancy Pearlman, David Waitkus-Edwards, Kelli Yancey, Steven Prillaman, Barbara A. Dorinsky, Paul |
| Description | Country affiliation: United States Author Affiliation: Koenig SM ( University of Virginia, Division of Pulmonary Medicine & Critical Care, Charlottesville, VA 22908, USA. smk4q@virginia.edu) |
| Abstract | In this study, 647 subjects stable on fluticasone propionate/salmeterol Diskus 100/50 mcg BID (FSC) were randomized to continue FSC 100/50 mcg BID or 'step down' to either fluticasone propionate (FP) 100 mcg BID, salmeterol (SAL) 50 mcg BID, or montelukast (MON) 10 mg once daily for 16 weeks. Overall asthma control significantly improved in the FSC group; whereas, 'stepping down' to FP, SAL, or MON resulted in deterioration in asthma control, as determined by decreased measures of lung function and clinical features. This study provides support that treatment of both inflammation and smooth muscle dysfunction may be necessary to achieve and maintain asthma control in patients uncontrolled on ICS. |
| File Format | HTM / HTML |
| ISSN | 02770903 |
| Issue Number | 8 |
| Volume Number | 45 |
| e-ISSN | 15324303 |
| Journal | Journal of Asthma |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonology Acetates Administration & Dosage Albuterol Analogs & Derivatives Androstadienes Anti-asthmatic Agents Asthma Drug Therapy Quinolines Physiopathology Dose-response Relationship, Drug Double-blind Method Drug Combinations Female Fluticasone Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Forced Expiratory Flow Rates Drug Effects Humans Kaplan-meier Estimate Male Patient Satisfaction Peak Expiratory Flow Rate Salmeterol Xinafoate Questionnaires Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Pediatrics, Perinatology and Child Health |
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